(Nle4)-α-MSH
Modify Date: 2024-02-14 23:59:55
(Nle4)-α-MSH structure
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Common Name | (Nle4)-α-MSH | ||
|---|---|---|---|---|
| CAS Number | 64887-70-3 | Molecular Weight | 1646.845 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C78H111N21O19 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of (Nle4)-α-MSH(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1]. |
| Name | 4-L-Norleucine-alpha-Melanotropin |
|---|---|
| Synonym | More Synonyms |
| Description | (Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment[1]. |
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| Related Catalog | |
| Target |
tyrosinase; melanoma adenylate cyclase[1] |
| In Vitro | (Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity[1]. (Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)[1]. (Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins[1]. (Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase[1]. |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Molecular Formula | C78H111N21O19 |
| Molecular Weight | 1646.845 |
| Exact Mass | 1645.836548 |
| PSA | 642.98000 |
| LogP | -0.80 |
| Index of Refraction | 1.674 |
| L-Valinamide, N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl- |
| (4-Norleucine)Alpha-Msh |
| 4-Nle-Alpha-Msh |
| N-Acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide |
| Msh, 4-Nle-Alpha- |
| N-acetyl-L-seryl-L-tyrosyl-L-seryl-L-norleucyl-L-α-glutamyl-L-histidyl-L-phenylalanyl-N-(diaminomethylidene)-L-ornithyl-L-tryptophylglycyl-L-lysyl-L-prolyl-L-valinamide |