Ethacrynic acid sodium

Modify Date: 2024-01-02 17:30:40

Ethacrynic acid sodium Structure
Ethacrynic acid sodium structure
Common Name Ethacrynic acid sodium
CAS Number 6500-81-8 Molecular Weight 325.12
Density N/A Boiling Point 480ºC at 760 mmHg
Molecular Formula C13H11Cl2NaO4 Melting Point 121-122ºC
MSDS N/A Flash Point 244.1ºC

 Use of Ethacrynic acid sodium


Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].

 Names

Name sodium,2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetate
Synonym More Synonyms

 Ethacrynic acid sodium Biological Activity

Description Ethacrynic acid (Etacrynic acid sodium) sodium is a diuretic. Ethacrynic acid sodium is an inhibitor of glutathione S-transferases (GSTs). Ethacrynic acid sodium is a potent inhibitor of NF-kB-signaling pathway, and also modulates leukotriene formation. Ethacrynic acid sodium also inhibits L-type voltage-dependent and store-operated calcium channel, leading to relaxation of airway smooth muscle (ASM) cells. Ethacrynic acid sodium has anti-inflammatory properties that reduces the retinoid-induced ear edema in mice[1][2][3][4].
Related Catalog
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.  

 Chemical & Physical Properties

Boiling Point 480ºC at 760 mmHg
Melting Point 121-122ºC
Molecular Formula C13H11Cl2NaO4
Molecular Weight 325.12
Flash Point 244.1ºC
Exact Mass 323.99300
PSA 66.43000
LogP 2.27100
Storage condition -20°C

 Safety Information

Hazard Codes Xi

 Synonyms

UNII-K41MYV7MPM
Edecrin Sodium
Acetic acid,(2,3-dichloro-4-(2-methylene-1-oxobutyl)phenoxy)-,sodium salt
ETHACRYNATE SODIUM
Ethacrynate sodium (USP)
Sodium ethacrynate
Ethacrynic acid sodium
Sodium edecrin