L-152,804
Modify Date: 2024-01-03 09:55:19
L-152,804 structure
|
Common Name | L-152,804 | ||
|---|---|---|---|---|
| CAS Number | 6508-43-6 | Molecular Weight | 366.45000 | |
| Density | 1.23g/cm3 | Boiling Point | 506.7ºC at 760 mmHg | |
| Molecular Formula | C23H26O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 173ºC | |
| Symbol |
GHS06, GHS09 |
Signal Word | Danger | |
Use of L-152,804L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2]. |
| Name | L-152,804,5,5-Dimethyl-2-(2,3,4,9-tetrahydro-3,3-dimethyl-1oxo-1H-xanthen-9-yl)-1,3-cyclohexanedione |
|---|---|
| Synonym | More Synonyms |
| Description | L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure[1][2]. |
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| Related Catalog | |
| Target |
Ki: 26 nM (NPY5-R)[1]. |
| In Vitro | L 152804 displays > 300-fold selectivity over hY1, hY2, and hY4 receptors[1]. |
| References |
| Density | 1.23g/cm3 |
|---|---|
| Boiling Point | 506.7ºC at 760 mmHg |
| Molecular Formula | C23H26O4 |
| Molecular Weight | 366.45000 |
| Flash Point | 173ºC |
| Exact Mass | 366.18300 |
| PSA | 60.44000 |
| LogP | 4.38020 |
| Index of Refraction | 1.603 |
| Storage condition | 2-8℃ |
| Symbol |
GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H410 |
| Precautionary Statements | P273-P301 + P310-P501 |
| RIDADR | UN2811 - class 6.1 - PG 3 - EHS - Toxic solids, organic, n.o.s., HI: all |
|
~92%
L-152,804 CAS#:6508-43-6 |
| Literature: Pyrko Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 6 p. 635 - 645 |
|
~10%
L-152,804 CAS#:6508-43-6
Detail
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| Literature: Ganguly, Nemai C.; Roy, Sushmita; Mondal, Pallab; Saha, Rajat Tetrahedron Letters, 2012 , vol. 53, # 52 p. 7067 - 7071 |
|
~39%
L-152,804 CAS#:6508-43-6 |
| Literature: Gusak; Tereshko; Kozlov Russian Journal of Organic Chemistry, 2001 , vol. 37, # 10 p. 1495 - 1502 |
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| 9-dimedonyl-3,3-dimethyl-1,2,3,4-tetrahydro-9H-xanthen-1-one |
| 9-<4,4-Dimethyl-2,6-dioxo-cyclohexyl>-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-xanthen |
| L-152,804 |