Guttiferone G

Modify Date: 2024-07-17 08:03:10

Guttiferone G Structure
Guttiferone G structure
Common Name Guttiferone G
CAS Number 666174-75-0 Molecular Weight 670.92
Density 1.088±0.06 g/cm3(Predicted) Boiling Point 756.4±60.0 °C(Predicted)
Molecular Formula C43H58O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Guttiferone G


Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla[1][2].

 Names

Name Guttiferone G

 Guttiferone G Biological Activity

Description Guttiferone G inhibits recombinant human SIRT1 and SIRT2 (IC50: 9 and 22 μM, respectively). Guttiferone G is weakly cytotoxic in A2780 human ovarian cell line (IC50: 8.0 μg/mL). Guttiferone G can be isolated from Garcinia macrophylla[1][2].
Related Catalog
Target

IC50: 9 and 22 μM (SIRT1/2)[1]

References

[1]. Williams RB, et al. A novel cytotoxic guttiferone analogue from Garcinia macrophylla from the Suriname rainforest. Planta Med. 2003 Sep;69(9):864-6.  

[2]. Gey C, et al. Phloroglucinol derivatives guttiferone G, aristoforin, and hyperforin: inhibitors of human sirtuins SIRT1 and SIRT2. Angew Chem Int Ed Engl. 2007;46(27):5219-22.  

 Chemical & Physical Properties

Density 1.088±0.06 g/cm3(Predicted)
Boiling Point 756.4±60.0 °C(Predicted)
Molecular Formula C43H58O6
Molecular Weight 670.92