pralidoxime

Modify Date: 2024-01-08 20:43:05

pralidoxime structure	Common Name	pralidoxime
	CAS Number	6735-59-7	Molecular Weight	137.15900
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇H₉N₂O+	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of pralidoxime

Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning[1][2].

Name	pralidoxime
Synonym	More Synonyms

Description	Pralidoxime is a potent reactivator of acetylcholinesterase (AChE). Pralidoxime reactivates nerve agent-inhibited AChE via direct nucleophilic attack by the oxime moiety on the phosphorus center of the bound nerve agent. Pralidoxime is an antidote for organophosphate poisoning[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	Acetylcholinesterase
In Vivo	Pralidoxime (10-150 mg/kg; intramuscular administration, once) reverses paraoxon-induced respiratory toxicity in mice[3]. Animal Model: F1B6D2 mice (male, administered subcutaneously diethylparaoxon)[3] Dosage: 10, 50, 100, and 150 mg/kg Administration: Intramuscular administration, once Result: Induced a partial, albeit complete, reversal of respiratory toxicity at 50 mg/kg, and completely reversed diethylparaoxon-induced respiratory toxicity in mice at 150 mg/kg.
References	[1]. Cadieux CL, et al. Probing the activity of a non-oxime reactivator for acetylcholinesterase inhibited by organophosphorus nerve agents. Chem Biol Interact. 2016;259(Pt B):133‐141. [2]. Eyer P, Buckley N. Pralidoxime for organophosphate poisoning. Lancet. 2006;368(9553):2110‐2111. [3]. Houzé P, et al. High Dose of Pralidoxime Reverses Paraoxon-Induced Respiratory Toxicity in Mice. Turk J Anaesthesiol Reanim. 2018;46(2):131‐138.

Molecular Formula	C₇H₉N₂O+
Molecular Weight	137.15900
Exact Mass	137.07100
PSA	36.47000
LogP	0.31920

Conthrathion

2-(hydroxyimino-methyl)-1-methyl-pyridinium

PRALIDOXIME

N-Methyl-2-pyridyl-aldoxim-hydroxid

2-PAM

2-(Hydroxyiminomethyl)-1-methylpyridinium

2-(hydroximinomethyl)-1-methylpyridinium cation

(2-Hydroxyimino-methyl)-1-methyl-pyridinium

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Pralidoxime
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Contact: Ms Wang
Email: enquiry@dycnchem.com

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