(S)-(-)-Blebbistatin

Modify Date: 2024-01-09 20:31:20

(S)-(-)-Blebbistatin Structure
(S)-(-)-Blebbistatin structure
Common Name (S)-(-)-Blebbistatin
CAS Number 674289-55-5 Molecular Weight 292.332
Density 1.3±0.1 g/cm3 Boiling Point 507.3±60.0 °C at 760 mmHg
Molecular Formula C18H16N2O2 Melting Point 210-212ºC
MSDS N/A Flash Point 260.6±32.9 °C

 Use of (S)-(-)-Blebbistatin


Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function[1].

 Names

Name blebbistatin
Synonym More Synonyms

 (S)-(-)-Blebbistatin Biological Activity

Description Blebbistatin is a selective non-muscle myosin II (NMII) inhibitor, promotes directional migration of corneal endothelial cells (CECs) and accelerates wound healing, and better preserves cell junctional integrity and barrier function[1].
Related Catalog
Target

Non-muscle myosin II (NMII)[1]

In Vitro The therapeutic potential of targeting NMII to enhance CEC migration is investigated using bovine corneal endothelial cells (BCECs). Blebbistatin, a direct myosin motor inhibitor, promotes migration and directional persistence in CECs through decreasing actin retrograde flow and increasing lamellipodial protrusion persistence to accelerate wound healing in vitro[1].
In Vivo Blebbistatin (0.05 mL, 20 μM; intracameral injection; daily; for 6 days; New Zealand white rabbits) treatment promotes wound healing in rabbit corneal endothelial scraping model[1]. Animal Model: New Zealand white rabbits (16-20 weeks; 3-3.5 kg) with injected xylazine 5 mg/kg and ketamine 40 mg/kg[1] Dosage: 0.05 mL; 20 μM Administration: Intracameral injection; daily; for 6 days Result: Resulted in significant improvement of corneal clarity and corneal edema resolution, implying the restoration of an intact corneal endothelial monolayer.
References

[1]. Ho WT, et al. Targeting non-muscle myosin II promotes corneal endothelial migration through regulating lamellipodial dynamics. J Mol Med (Berl). 2019 Sep;97(9):1345-1357.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 507.3±60.0 °C at 760 mmHg
Melting Point 210-212ºC
Molecular Formula C18H16N2O2
Molecular Weight 292.332
Flash Point 260.6±32.9 °C
Exact Mass 292.121185
PSA 52.90000
LogP 1.62
Vapour Pressure 0.0±1.4 mmHg at 25°C
Index of Refraction 1.681

 Safety Information

Hazard Codes Xn
Risk Phrases R20/21/22
Safety Phrases 26-36/37

 Synonyms

(−)-Blebbistatin
(+/-)-Blebbistatin
(3aS)-3a-Hydroxy-6-methyl-1-phenyl-1,2,3,3a-tetrahydro-4H-pyrrolo[2,3-b]quinolin-4-one
Blebbistatin
4H-Pyrrolo[2,3-b]quinolin-4-one, 1,2,3,3a-tetrahydro-3a-hydroxy-6-methyl-1-phenyl-, (3aS)-
(S)-Blebbistatin
3a-hydroxy-6-methyl-1-phenyl-2,3-dihydropyrrolo[2,3-b]quinolin-4-one
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