aurantio-obtusin

Modify Date: 2024-01-03 18:24:03

aurantio-obtusin Structure
aurantio-obtusin structure
 Common Name aurantio-obtusin
CAS Number 67979-25-3 Molecular Weight 330.289
Density 1.5±0.1 g/cm3 Boiling Point 594.6±50.0 °C at 760 mmHg
Molecular Formula C17H14O7 Melting Point N/A
MSDS N/A Flash Point 222.4±23.6 °C

 Use of aurantio-obtusin


Aurantio-obtusin is an anthraquinone isolated from Semen Cassiae, with anti-Inflammatory, anti-oxidative, anti-coagulating and anti-hypertension activities[1][2][3]. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats, thus acts as a new potential vasodilator[2]. Aurantio-obtusin inhibits allergic responses in IgE-mediated mast cells and anaphylactic models and is potential for treatment for allergy-related diseases[3].

 Names

Name aurantio-obtusin
Synonym More Synonyms

 aurantio-obtusin Biological Activity

Description Aurantio-obtusin is an anthraquinone isolated from Semen Cassiae, with anti-Inflammatory, anti-oxidative, anti-coagulating and anti-hypertension activities[1][2][3]. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats, thus acts as a new potential vasodilator[2]. Aurantio-obtusin inhibits allergic responses in IgE-mediated mast cells and anaphylactic models and is potential for treatment for allergy-related diseases[3].
Related Catalog
References

[1]. Hou J, et al. Anti-Inflammatory Effects of Aurantio-Obtusin from Seed of Cassia obtusifolia L. through Modulation of the NF-κB Pathway. Molecules. 2018 Nov 27;23(12).

[2]. Li S, et al. Aurantio-obtusin relaxes systemic arteries through endothelial PI3K/AKT/eNOS-dependent signaling pathway in rats. J Pharmacol Sci. 2015 Jul;128(3):108-15.

[3]. Kim M, et al. Cassia tora Seed Extract and Its Active Compound Aurantio-obtusin Inhibit Allergic Responses in IgE-Mediated Mast Cells and Anaphylactic Models. J Agric Food Chem. 2015 Oct 21;63(41):9037-46.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 594.6±50.0 °C at 760 mmHg
Molecular Formula C17H14O7
Molecular Weight 330.289
Flash Point 222.4±23.6 °C
Exact Mass 330.073944
PSA 113.29000
LogP 3.81
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.679
Storage condition 2~8℃

 Safety Information

Hazard Codes Xn
Safety Phrases 24/25

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

9,10-Anthracenedione, 1,3,7-trihydroxy-2,8-dimethoxy-6-methyl-
aurantio-obtusin
1,3,7-trihydroxy-2,8-dimethoxy-6-methylanthracene-9,10-dione
1,3,7-Trihydroxy-2,8-dimethoxy-6-methyl-9,10-anthraquinone
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