Lagosin

Modify Date: 2024-01-06 16:23:52

Lagosin Structure
Lagosin structure
Common Name Lagosin
CAS Number 6834-98-6 Molecular Weight 670.83
Density 1.196g/cm3 Boiling Point 914ºC at 760 mmHg
Molecular Formula C35H58O12 Melting Point N/A
MSDS N/A Flash Point 278.4ºC

 Use of Lagosin


Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to drug resistance[1].

 Names

Name (3R,4S,6S,8S,10R,12R,14R,15R,16R,17E,19E,21E,23E,25E,27S,28R)-4,6,8,10,12,14,15,16,27-nonahydroxy-3-[(1R)-1-hydroxyhexyl]-17,28-dimethyl-1-oxacyclooctacosa-17,19,21,23,25-pentaen-2-one
Synonym More Synonyms

 Lagosin Biological Activity

Description Lagosin (Fungichromin) is a polyene macrolide antibiotic. Lagosin has demonstrated broad-spectrum antifungal activity and is impervious to drug resistance[1].
Related Catalog
In Vitro Lagosin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum[1].
References

[1]. Peng C, et al. Fungichromin production by Streptomyces sp. WP-1, an endophyte from Pinus dabeshanensis, and its antifungal activity against Fusarium oxysporum. Appl Microbiol Biotechnol. 2020;104(24):10437-10449.

 Chemical & Physical Properties

Density 1.196g/cm3
Boiling Point 914ºC at 760 mmHg
Molecular Formula C35H58O12
Molecular Weight 670.83
Flash Point 278.4ºC
Exact Mass 670.39300
PSA 228.60000
LogP 0.85880
Index of Refraction 1.545

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LT3850000
CHEMICAL NAME :
Fungichromin
CAS REGISTRY NUMBER :
6834-98-6
LAST UPDATED :
199512
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C35-H58-O12
MOLECULAR WEIGHT :
670.93
WISWESSER LINE NOTATION :
T-28-OV RU TU VU A&U C&UTJ CYQ5 DQ FQ HQ JQ LQ NQ OQ PQ R1 E&Q F&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1624 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JAJAAA Journal of Antibiotics, Series A. (Tokyo, Japan) V.6-20, 1953-67. For publisher information, see JANTAJ. Volume(issue)/page/year: 11,26,1958
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
16400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ABANAE Antibiotics Annual. (New York, NY) 1953-60. For publisher information, see AMACCQ. Volume(issue)/page/year: 2,716,1954/1955

 Synonyms

Pentamycin
S 232
all-trans-3,5,7,9,11,13,14,15,26,27-Decahydroxy-2,1'-hydroxyhexyl-16-methyl-octacosa-16,18,20,22,24-pentaen-saeure-1->27-lacton
14-Hydroxyfilipin
Cogomycin
Antibiotic A-246
Lagosin (antibiotic)
EINECS 229-913-4
Lagosin
Fungichromin