7-Methoxy-1-tetralone

Modify Date: 2024-01-01 20:17:16

7-Methoxy-1-tetralone structure	Common Name	7-Methoxy-1-tetralone
	CAS Number	6836-19-7	Molecular Weight	176.21
	Density	1.1±0.1 g/cm3	Boiling Point	312.3±31.0 °C at 760 mmHg
	Molecular Formula	C₁₁H₁₂O₂	Melting Point	59-63 °C(lit.)
	MSDS	Chinese USA	Flash Point	145.8±18.4 °C

Use of 7-Methoxy-1-tetralone

7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].

Name	7-Methoxy-1-tetralone
Synonym	More Synonyms

Description	7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
In Vitro	7-Methoxy-1-tetralone (31.25-1000 μM; 48 h) 抑制 LO2 和 HepG2 细胞的增殖活性[1]。 7-Methoxy-1-tetralone (40 μM, 100 μM, 250 μM; 48 h) 诱导 HepG2 细胞凋亡，调节细胞中 c-Met、p-AKT、AKT、NF-κB、MMP2、MMP9 蛋白的表达水平[1]。 Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 40 μM, 100 μM, and 250 μM Incubation Time: 48 h Result: Decreased the protein expression levels of c-Met, p-AKT, NF-κB, MMP2, and MMP9. Cell Proliferation Assay[1] Cell Line: LO2 and HepG2 cells Concentration: 31.25 μM, 62.5 μM, 125 μM, 250 μM, 500 μM, and 1000 μM Incubation Time: 24 h, 48 h, and 72 h Result: Exhibited anti-proliferative activity of MT on LO2 and HepG2 cells.
In Vivo	7-Methoxy-1-tetralone (80, 120, or 160 mg/kg/d；腹腔注射；共 19 次剂量) 抑制 HepG2 细胞皮下植入肿瘤模型的肿瘤生长[1]。 Animal Model: BALB/c nude mice (5-week-old) with subcutaneously implanted HepG2 cells[1] Dosage: 80, 120, or 160 mg/kg/d Administration: Intraperitoneal injection; sacrificed after 19 days Result: Resulted the tumor inhibition rates of 40.57% (80 mg/kg), 51.43% (120 mg/kg), 79.43% (160 mg/kg), respectively.
References	[1]. Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58.

Density	1.1±0.1 g/cm3
Boiling Point	312.3±31.0 °C at 760 mmHg
Melting Point	59-63 °C(lit.)
Molecular Formula	C₁₁H₁₂O₂
Molecular Weight	176.21
Flash Point	145.8±18.4 °C
Exact Mass	176.083725
PSA	26.30000
LogP	2.79
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.549
Storage condition	2~8°C

7-Methoxy-1-tetralone MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2914509090

Precursor 9
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HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%