6836-19-7

6836-19-7 structure

Name: 7-Methoxy-1-tetralone
Chemical Name: 7-Methoxy-1-tetralone
CAS Number: 6836-19-7
Molecular Formula: C₁₁H₁₂O₂
Molecular Weight: 176.21
Catalog: Chemical reagent Organic reagent Polycyclic compound
Create Date: 2018-09-07 00:19:33
Modify Date: 2024-01-01 20:17:16
7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].

Name	7-Methoxy-1-tetralone
Synonyms	EINECS 229-916-0 3,4-dihydro-7-methoxynaphthalen-1(2H)-one 7-Methoxy-3,4-dihydronaphthalen-1(2H)-one 1(2H)-Naphthalenone, 3,4-dihydro-7-methoxy- MFCD00001696 7-Methoxy-3,4-dihydro-1(2H)-naphthalenone 7-methoxy-3,4-dihydro-2H-naphthalen-1-one

Description	7-Methoxy-1-tetralone is a potent antitumor agent. 7-Methoxy-1-tetralone inhibits cancer cell proliferation and migration, and induces hepatocellular carcinoma cell (HCC) apoptosis. 7-Methoxy-1-tetralone decreased the protein levels of NF-κB, matrix metallopeptidase 2 (MMP2)/MMP9, and p-AKT. 7-Methoxy-1-tetralone showed antitumor activity in nude mice and had no effect on body weight and liver, spleen and organ index[1].
Related Catalog	Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Signaling Pathways >> PI3K/Akt/mTOR >> Akt Signaling Pathways >> Metabolic Enzyme/Protease >> MMP Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Met/HGFR
In Vitro	7-Methoxy-1-tetralone (31.25-1000 μM; 48 h) 抑制 LO2 和 HepG2 细胞的增殖活性[1]。 7-Methoxy-1-tetralone (40 μM, 100 μM, 250 μM; 48 h) 诱导 HepG2 细胞凋亡，调节细胞中 c-Met、p-AKT、AKT、NF-κB、MMP2、MMP9 蛋白的表达水平[1]。 Western Blot Analysis[1] Cell Line: HepG2 cells Concentration: 40 μM, 100 μM, and 250 μM Incubation Time: 48 h Result: Decreased the protein expression levels of c-Met, p-AKT, NF-κB, MMP2, and MMP9. Cell Proliferation Assay[1] Cell Line: LO2 and HepG2 cells Concentration: 31.25 μM, 62.5 μM, 125 μM, 250 μM, 500 μM, and 1000 μM Incubation Time: 24 h, 48 h, and 72 h Result: Exhibited anti-proliferative activity of MT on LO2 and HepG2 cells.
In Vivo	7-Methoxy-1-tetralone (80, 120, or 160 mg/kg/d；腹腔注射；共 19 次剂量) 抑制 HepG2 细胞皮下植入肿瘤模型的肿瘤生长[1]。 Animal Model: BALB/c nude mice (5-week-old) with subcutaneously implanted HepG2 cells[1] Dosage: 80, 120, or 160 mg/kg/d Administration: Intraperitoneal injection; sacrificed after 19 days Result: Resulted the tumor inhibition rates of 40.57% (80 mg/kg), 51.43% (120 mg/kg), 79.43% (160 mg/kg), respectively.
References	[1]. Wen Y, et al. 7-Methoxy-1-Tetralone Induces Apoptosis, Suppresses Cell Proliferation and Migration in Hepatocellular Carcinoma via Regulating c-Met, p-AKT, NF-κB, MMP2, and MMP9 Expression. Front Oncol. 2020 Feb 7;10:58.

Density	1.1±0.1 g/cm3
Boiling Point	312.3±31.0 °C at 760 mmHg
Melting Point	59-63 °C(lit.)
Molecular Formula	C₁₁H₁₂O₂
Molecular Weight	176.21
Flash Point	145.8±18.4 °C
Exact Mass	176.083725
PSA	26.30000
LogP	2.79
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.549
Storage condition	2~8°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	R20/21/22
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2914509090

Precursor 9
4521-28-2 32820-10-3 1730-48-9 106336-27-0
6836-18-6 87543-05-3 666177-27-1 3153-44-4
87543-11-1
DownStream 10
31846-36-3 4133-34-0 22246-83-9 22246-71-5
19393-87-4 19307-13-2 30021-91-1 26593-50-0
2800-94-4 861960-34-1

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

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