BX 430

Modify Date: 2024-01-22 18:46:33

BX 430 structure	Common Name	BX 430
	CAS Number	688309-70-8	Molecular Weight	413.107
	Density	1.7±0.1 g/cm3	Boiling Point	395.4±42.0 °C at 760 mmHg
	Molecular Formula	C₁₅H₁₅Br₂N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	192.9±27.9 °C

Use of BX 430

BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.

Name	1-(2,6-Dibromo-4-isopropylphenyl)-3-(3-pyridinyl)urea
Synonym	More Synonyms

Description	BX430 is a potent and selective noncompetitive allosteric human P2X4 receptor channels antagonist with an IC50 of 0.54 μM. BX430 has species specificity. BX430 is used for chronic pain and cardiovascular disease.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Research Areas >> Cardiovascular Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> P2X Receptor
Target	IC50: 0.54 μM (human P2X4 receptor channels)[1]
In Vitro	BX430 has virtually no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7, at 10-100 times its IC50[1]. BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs[1]. Human P2X4-expressing cells treated with thapsigargin plus BX430 shows a significant reduction in the intracellular calcium rise evoked by ATP[1]. BX430 (5 μM) markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells[1].
References	[1]. Ase AR, et al. Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels. Mol Pharmacol. 2015 Apr;87(4):606-16. [2]. Sophocleous RA, et al. Pharmacological and genetic characterisation of the canine P2X4 receptor. Br J Pharmacol. 2020 Feb 4.

Density	1.7±0.1 g/cm3
Boiling Point	395.4±42.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₅Br₂N₃O
Molecular Weight	413.107
Flash Point	192.9±27.9 °C
Exact Mass	410.958160
LogP	4.56
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.679

Hazard Codes	Xn

1-(2,6-Dibromo-4-isopropylphenyl)-3-(3-pyridinyl)urea

N-(2,6-dibromo-4-isopropylphenyl)-N'-(3-pyridinyl)urea

Urea, N-[2,6-dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: BX 430
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: BX430
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: BX430
Price: $600.0/100mg $1100.0/250mg $2200.0/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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