SPL 334
Modify Date: 2024-01-12 17:59:11
SPL 334 structure
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Common Name | SPL 334 | ||
|---|---|---|---|---|
| CAS Number | 688347-51-5 | Molecular Weight | 433.503 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 694.0±65.0 °C at 760 mmHg | |
| Molecular Formula | C22H15N3O3S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 373.5±34.3 °C | |
Use of SPL 334SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1]. |
| Name | SPL-334 |
|---|---|
| Synonym | More Synonyms |
| Description | SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1]. |
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| Related Catalog | |
| In Vivo | SPL-334 (0.1-1 mg/kg; 鼻内给药; 每日一次, 持续 7 天; 带有 DO11.10 CD4+ Th2 异种移植物的 BALB/c 受体小鼠) 导致过敏性气道炎症减少[1] . Animal Model: BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft[1] Dosage: 0.1 or 1 mg/kg Administration: Intranasal administration; daily, for 7 days Result: Caused a significant reduction in the influx of lymphocytes and eosinophils into the airways and the level of EPO in the BALF. Reduced the number of OVA-specific T cells and eosinophils during allergic airway inflammation. Reduced in peribronchial inflammation and mucus secretion during airway inflammation. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 694.0±65.0 °C at 760 mmHg |
| Molecular Formula | C22H15N3O3S2 |
| Molecular Weight | 433.503 |
| Flash Point | 373.5±34.3 °C |
| Exact Mass | 433.055481 |
| LogP | 3.85 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.721 |
| 4-{[2-[(2-cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid |
| Benzoic acid, 4-[[2-[[(2-cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]- |
| 4-({2-[(2-Cyanobenzyl)sulfanyl]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl}methyl)benzoic acid |
| SPL-334 |
| MFCD05032783 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: SPL 334
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: SPL-334
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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