Hypaconitine

Modify Date: 2024-01-02 14:37:17

Hypaconitine structure	Common Name	Hypaconitine
	CAS Number	6900-87-4	Molecular Weight	615.711
	Density	1.4±0.1 g/cm3	Boiling Point	671.3±55.0 °C at 760 mmHg
	Molecular Formula	C₃₃H₄₅NO₁₀	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	359.8±31.5 °C
	Symbol	GHS06	Signal Word	Danger

Use of Hypaconitine

Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value:Target:In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1].In vivo:

Name	Hypaconitine
Synonym	More Synonyms

Description	Hypaconitine, an active and highly toxic constituent derived from Aconitum species, is widely used to treat rheumatism. IC50 value:Target:In vitro: The present study investigated the metabolism of hypaconitine in vitro using male human liver microsomes. The primary contributors toward HA metabolism were CYP3A4 and 3A5, with secondary contributions by CYP2C19, 2D6 and CYP2E1 [1].In vivo:
Related Catalog	Signaling Pathways >> Apoptosis >> TNF Receptor Natural Products >> Alkaloid Research Areas >> Inflammation/Immunology
References	[1]. Ling Ye, et al. Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicology letters, 2011, 204 (1): 81-91 [2]. Yang Yuan, et al. Difference of hypaconitine concentration in serum between cold-deficiency and normal mice. China Journal of Chinese Materia Medica, 2010-15 [3]. Zhang Jinming, Compatibility Effect between Radix Aconiti Lateralis and Radix Glycyrrhizae on Pharmacokinetics of Hypaconitine in Rat Plasma by LC-MS/MS. World Science Technology-Modernization of Traditional Chinese Medicine, 2011-06

Description

Related Catalog

Signaling Pathways >> Apoptosis >> TNF Receptor

Natural Products >> Alkaloid

Research Areas >> Inflammation/Immunology

References

[1]. Ling Ye, et al. Microsomal cytochrome P450-mediated metabolism of hypaconitine, an active and highly toxic constituent derived from Aconitum species. Toxicology letters, 2011, 204 (1): 81-91

[2]. Yang Yuan, et al. Difference of hypaconitine concentration in serum between cold-deficiency and normal mice. China Journal of Chinese Materia Medica, 2010-15

[3]. Zhang Jinming, Compatibility Effect between Radix Aconiti Lateralis and Radix Glycyrrhizae on Pharmacokinetics of Hypaconitine in Rat Plasma by LC-MS/MS. World Science Technology-Modernization of Traditional Chinese Medicine, 2011-06

Density	1.4±0.1 g/cm3
Boiling Point	671.3±55.0 °C at 760 mmHg
Molecular Formula	C₃₃H₄₅NO₁₀
Molecular Weight	615.711
Flash Point	359.8±31.5 °C
Exact Mass	615.304321
PSA	133.22000
LogP	0.92
Vapour Pressure	0.0±2.2 mmHg at 25°C
Index of Refraction	1.607

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AR5565000

CHEMICAL NAME :: Aconitane-8,13,14,15-tetraol, 16,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate benzoate, (1-alpha,6-alpha,14-alpha,15-alpha,16-beta)-

CAS REGISTRY NUMBER :: 6900-87-4

LAST UPDATED :: 199412

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C33-H45-N-O10

MOLECULAR WEIGHT :: 615.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5800 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1010 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 2,170,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1900 ug/kg

TOXIC EFFECTS :: Behavioral - ataxia Lungs, Thorax, or Respiration - other changes

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 35,159,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 470 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 4,247,1981

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H300
Precautionary Statements	P301 + P310 + P330
Safety Phrases	24/25
RIDADR	UN 1544
Packaging Group	I
Hazard Class	6.1(a)
HS Code	29399990

3-O-(imidazolyl...

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~92%

Hypaconitine

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Literature: Kulanthaivel, Palaniappan; Pelletier, S. William Tetrahedron, 1988 , vol. 44, # 14 p. 4313 - 4320

N-desethylaconitine

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Hypaconitine

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Mesaconitine

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Hypaconitine

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Aconitine

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Hypaconitine

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3-O-(S-methyl)t...

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~94%

Hypaconitine

CAS#:6900-87-4

Literature: Mori; Murayama; Bando; Kawahara Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 11 p. 2803 - 2806

Precursor 5
CAS#:121236-31-5 3-O-(imidazolyl... CAS#:3327-35-3 N-desethylaconitine CAS#:2752-64-9 Mesaconitine CAS#:302-27-2 Aconitine
CAS#:139617-07-5 3-O-(S-methyl)t...
DownStream 2
CAS#:64-19-7 acetic acid CAS#:65-85-0 benzoic acid

Japaconitine C1

HYPACONITINE (PRIMARY STANDARD)

Aconitane-8,13,14,15-tetrol, 1,6,16-trimethoxy-4-(methoxymethyl)-20-methyl-, 8-acetate 14-benzoate, (1α,6α,14α,15α,16β)-

Japaconitine B1

(1α,6α,14α,15α,16β)-8-(acetyloxy)-13,15-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-20-methylaconitan-14-yl benzoate

DEOXYMESACONITINE

15-tetraol,16,16-trimethoxy-4-(methoxymethyl)-20-methyl-18-aconitane-14

(1α,6α,14α,15α,16β)-8-Acetoxy-13,15-dihydroxy-1,6,16-trimethoxy-4-(methoxymethyl)-20-methylaconitan-14-yl benzoate

Japaconitine C

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Hypaconitine
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

BioBioPha
China
Product Name: Hypaconitine
Price: ￥Inquiry/5mg
Purity: 98.0%
Delivery: 10 Day
Contact: Xueping-Zheng
Email: 1477035482@qq.com

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: Hypaconitine
Price: ￥688.0/20mg
Purity: 98.0%
Delivery: 2 Day
Contact: Liu jia
Email: 2130147988@qq.com

DC Chemicals Limited
China
Product Name: Hypaconitine
Price: $280.0/20mg
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Hypaconitine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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Hypaconitine suppliers

Price: $172/10mM*1mLinDMSO

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Hypaconitine

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