Balapiravir hydrochloride

Modify Date: 2024-01-10 18:15:11

Balapiravir hydrochloride Structure
Balapiravir hydrochloride structure
Common Name Balapiravir hydrochloride
CAS Number 690270-65-6 Molecular Weight 530.95900
Density N/A Boiling Point N/A
Molecular Formula C21H31ClN6O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Balapiravir hydrochloride


Balapiravir hydrochloride (Ro 4588161 hydrochloride; R1626 hydrochloride) is an orally active prodrug of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir hydrochloride has anti-HCV activity[1][2][3].

 Names

Name [(2R,3S,4R,5R)-5-(4-amino-2-oxopyrimidin-1-yl)-2-azido-3,4-bis(2-methylpropanoyloxy)oxolan-2-yl]methyl 2-methylpropanoate,hydrochloride
Synonym More Synonyms

 Balapiravir hydrochloride Biological Activity

Description Balapiravir hydrochloride (Ro 4588161 hydrochloride; R1626 hydrochloride) is an orally active prodrug of a nucleoside analogue inhibitor of the RNA-dependent RNA polymerase (RdRp) of HCV (R1479; 4'-Azidocytidine). Balapiravir hydrochloride has anti-HCV activity[1][2][3].
Related Catalog
In Vitro After oral dosing of the CD-1 mice with 28.1 mg/kg of balapiravir (Ro 4588161 hydrochloride; R1626 hydrochloride), R1479 reaches a Cmax and a minimum concentration in plasma (Cmin) of 24.38 μM and 6.34 μM, respectively, at 2 h and 24 h postdosing[3].
References

[1]. Nguyen NM, et al. A randomized, double-blind placebo controlled trial of balapiravir, a polymerase inhibitor, in adult dengue patients. J Infect Dis. 2013 May 1;207(9):1442-1450.

[2]. Nelson DR, et al. Balapiravir plus peginterferon alfa-2a (40KD)/ribavirin in a randomized trial of hepatitis C genotype 1 patients.Ann Hepatol. 2012 Jan-Feb;11(1):15-31.

[3]. Yen-Liang Chen, et al. Activation of Peripheral Blood Mononuclear Cells by Dengue Virus Infection Depotentiates Balapiravir. J Virol. 2014 Feb;88(3):1740-7.

 Chemical & Physical Properties

Molecular Formula C21H31ClN6O8
Molecular Weight 530.95900
Exact Mass 530.18900
PSA 199.78000
LogP 2.29286

 Synonyms

Balapiravir hydrochloride
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