5-Ethynyl uridine

Modify Date: 2024-01-03 21:38:48

5-Ethynyl uridine Structure
5-Ethynyl uridine structure
 Common Name 5-Ethynyl uridine
CAS Number 69075-42-9 Molecular Weight 268.22300
Density N/A Boiling Point N/A
Molecular Formula C11H12N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Ethynyl uridine


5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models[1][2].

 Names

Name 5-ethynyluridine
Synonym More Synonyms

 5-Ethynyl uridine Biological Activity

Description 5-Ethynyluridine (5-EU) is a potent cell-permeable nucleoside can be used to label newly synthesized RNA. 5-Ethynyluridine can be used for isolation and sequencing of nascent RNA from neuronal populations in vivo. 5-Ethynyluridine can be used to identify changes in transcription in vivo in nervous system disease models[1][2].
Related Catalog
In Vivo 5-Ethynyluridine (75 mM in PBS for 1 µl; intracerebellar injection ) shows a labeling of central nervous system cells in mouse[1]. 5-Ethynyluridine (330-750 µMol/g; i.p.) results in in labelling of nascent RNA in cells of multiple organs and tissues, but not in the central nervous system in mouse[1].
References

[1]. Van't Sant LJ, et al. In vivo 5-ethynyluridine (EU) labelling detects reduced transcription in Purkinje cell degeneration mouse mutants, but can itself induce neurodegeneration. Acta Neuropathol Commun. 2021 May 21;9(1):94.

[2]. Jao CY, et al. Exploring RNA transcription and turnover in vivo by using click chemistry. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15779-84.

 Chemical & Physical Properties

Molecular Formula C11H12N2O6
Molecular Weight 268.22300
Exact Mass 268.07000
PSA 124.78000

 Synthetic Route

uridine triacetate structure

uridine triacetate

CAS#:4105-38-8

~%

5-Ethynyl uridine Structure

5-Ethynyl uridine

CAS#:69075-42-9

Literature: Chemical Communications, , vol. 49, # 30 p. 3128 - 3130
5-Iodo-2',3',5'-tri-O-acetyluridine structure

5-Iodo-2',3',5'...

CAS#:84500-33-4

~%

5-Ethynyl uridine Structure

5-Ethynyl uridine

CAS#:69075-42-9

Literature: Chemical Communications, , vol. 49, # 30 p. 3128 - 3130
2',3',5'-O-triacetyl-5-[(trimethylsilyl)ethynyl]-uridine structure

2',3',5'-O-tria...

CAS#:140914-90-5

~%

5-Ethynyl uridine Structure

5-Ethynyl uridine

CAS#:69075-42-9

Literature: Chemical Communications, , vol. 49, # 30 p. 3128 - 3130
2',3',5'-O-triacetyl-5-ethynyl-uridine structure

2',3',5'-O-tria...

CAS#:209254-94-4

~%

5-Ethynyl uridine Structure

5-Ethynyl uridine

CAS#:69075-42-9

Literature: Chemical Communications, , vol. 49, # 30 p. 3128 - 3130
Uridine structure

Uridine

CAS#:58-96-8

~%

5-Ethynyl uridine Structure

5-Ethynyl uridine

CAS#:69075-42-9

Literature: Chemical Communications, , vol. 49, # 30 p. 3128 - 3130

 Synonyms

1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-ethynylpyrimidine-2,4(1H,3H)-dione
5-ETHYNYL URIDINE
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