2'-Deoxy-2'-fluorouridine

Modify Date: 2024-01-14 06:21:16

2'-Deoxy-2'-fluorouridine structure	Common Name	2'-Deoxy-2'-fluorouridine
	CAS Number	69123-94-0	Molecular Weight	246.19
	Density	1.6±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₉H₁₁FN₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 2'-Deoxy-2'-fluorouridine

1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	1-(2-Deoxy-2-fluoro-b-D-arabinofuranosyl)uracil
Synonym	More Synonyms

Description	1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog Research Areas >> Others
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Density	1.6±0.1 g/cm3
Molecular Formula	C₉H₁₁FN₂O₅
Molecular Weight	246.19
Exact Mass	246.065201
PSA	104.55000
LogP	-1.31
Index of Refraction	1.608
Storage condition	2-8°C

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YQ9512000

CHEMICAL NAME :: Uracil, 1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-

CAS REGISTRY NUMBER :: 69123-94-0

LAST UPDATED :: 198708

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C11-H15-F-N2-O5

MOLECULAR WEIGHT :: 274.28

WISWESSER LINE NOTATION :: T6NVMVJ E2 A- BT5OTJ CF DQ E1Q

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - rat Bone marrow

DOSE/DURATION :: 3700 umol/L

REFERENCE :: PAACA3 Proceedings of the American Association for Cancer Research. (Waverly Press, 428 E. Preston St., Baltimore, MD 21202) V.1- 1954- Volume(issue)/page/year: 26,333,1985