Biotin-C5-NHS Ester

Modify Date: 2024-01-02 16:08:25

Biotin-C5-NHS Ester structure	Common Name	Biotin-C5-NHS Ester
	CAS Number	72040-63-2	Molecular Weight	454.540
	Density	1.4±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₂₀H₃₀N₄O₆S	Melting Point	169-171 °C
	MSDS	USA	Flash Point	N/A

Use of Biotin-C5-NHS Ester

Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	Succinimidyl-6-(biotinamido) Hexanoate
Synonym	More Synonyms

Description	Biotin-C5-NHS Ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	Alkyl/ether
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Density	1.4±0.1 g/cm3
Melting Point	169-171 °C
Molecular Formula	C₂₀H₃₀N₄O₆S
Molecular Weight	454.540
Exact Mass	454.188599
PSA	159.21000
LogP	-1.62
Index of Refraction	1.591
Storage condition	−20°C
Stability	Moisture Sensitive
Water Solubility	H2O: ≤2 mg/mL with sonication

Biotin-C5-NHS Ester MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3

N-Hydroxysuccinimide

CAS#:6066-82-6

N-Biotinyl-6-am...

CAS#:72040-64-3

~56%

Biotin-C5-NHS Ester

CAS#:72040-63-2

Literature: Wang, Tzu-Pin; Chiou, Yi-Jang; Chen, Yi; Wang, Eng-Chi; Hwang, Long-Chih; Chen, Bing-Hung; Chen, Yen-Hsu; Ko, Chun-Han Bioconjugate Chemistry, 2010 , vol. 21, # 9 p. 1642 - 1655

biotin resistan...

CAS#:4443-68-9

Biotin-C5-NHS Ester

CAS#:72040-63-2

Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655

biotin-NHS ester

CAS#:85718-04-3

Biotin-C5-NHS Ester

CAS#:72040-63-2

Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655

6-Aminocaproic acid

CAS#:60-32-2

Biotin-C5-NHS Ester

CAS#:72040-63-2

Literature: Bioconjugate Chemistry, , vol. 21, # 9 p. 1642 - 1655

Precursor 5
CAS#:6066-82-6 N-Hydroxysuccinimide CAS#:72040-64-3 N-Biotinyl-6-am... CAS#:4443-68-9 biotin resistan... CAS#:85718-04-3 biotin-NHS ester
CAS#:60-32-2 6-Aminocaproic acid
DownStream 0

Avidin binding of carboxyl-substituted biotin and analogues.

Biochemistry 21 , 978-984, (1982)

Ligation of major histocompatability complex (MHC) class I molecules on human T cells induces cell death through PI-3 kinase-induced c-Jun NH2-terminal kinase activity: a novel apoptotic pathway distinct from Fas-induced apoptosis.

J. Cell Biol. 139 , 1523-1531, (1997)

Ligation of major histocompatability complex class I (MHC-I) molecules expressed on T cells leads to both growth arrest and apoptosis. The aim of the current study was to investigate the intracellular...

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage.

Genes Dev. 15 , 1067-1077, (2001)

The p53 tumor suppressor protein, a key regulator of cellular responses to genotoxic stress, is stabilized and activated after DNA damage. The rapid activation of p53 by ionizing radiation and radiomi...

(2,5-dioxopyrrolidin-1-yl) 6-[5-[(3aS,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoylamino]hexanoate

N-{6-[(2,5-dioxopyrrolidin-1-yl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

MFCD00065502

N-{6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl}-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide

1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[6-[(2,5-dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]hexahydro-2-oxo-, (3aS,4S,6aR)-