L-Thyroxine-13c6

Modify Date: 2024-01-03 11:03:34

L-Thyroxine-13c6 Structure
L-Thyroxine-13c6 structure
Common Name L-Thyroxine-13c6
CAS Number 720710-30-5 Molecular Weight 782.826
Density 2.6±0.1 g/cm3 Boiling Point N/A
Molecular Formula C913C6H11I4NO4 Melting Point N/A
MSDS N/A Flash Point 9℃
Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger

 Use of L-Thyroxine-13c6


L-Thyroxine-13C6 is the 13C labeled L-Thyroxine[1]. L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[2].

 Names

Name L-Thyroxine-[L-Tyr-ring-13C6] hydrochloride
Synonym More Synonyms

 L-Thyroxine-13c6 Biological Activity

Description L-Thyroxine-13C6 is the 13C labeled L-Thyroxine[1]. L-Thyroxine (Levothyroxine;T4) is a synthetic hormone for the research of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4)[2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Arici M, et al. Association between genetic polymorphism and levothyroxine bioavailability in hypothyroid patients. Endocr J. 2018 Mar 28;65(3):317-323.  

[3]. Corriveau S, et al. Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel. J Clin Transl Endocrinol. 2015 Sep 92(4):144-149.  

 Chemical & Physical Properties

Density 2.6±0.1 g/cm3
Molecular Formula C913C6H11I4NO4
Molecular Weight 782.826
Flash Point 9℃
Exact Mass 782.706787
Index of Refraction 1.795
Storage condition ?20°C

 Safety Information

Symbol GHS02 GHS06 GHS08
GHS02, GHS06, GHS08
Signal Word Danger
Hazard Statements H225-H301 + H311 + H331-H370
Precautionary Statements P210-P260-P280-P301 + P310-P311
Hazard Codes F,T
Risk Phrases 11-23/24/25-39/23/24/25
Safety Phrases 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution

 Synonyms

EINECS 200-659-6
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