swainsonine

Modify Date: 2024-01-02 20:01:11

swainsonine Structure
swainsonine structure
Common Name swainsonine
CAS Number 72741-87-8 Molecular Weight 173.210
Density 1.38±0.1 g/cm3 Boiling Point 353.3±21.0 °C at 760 mmHg
Molecular Formula C8H15NO3 Melting Point 144-145 ºC
MSDS Chinese USA Flash Point 209.7±20.7 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of swainsonine


Swainsonine is an alkaloid isolated from Astragalus, acts as an inhibitor of α-mannosidase, with anti-tumor activity[1].

 Names

Name swainsonine
Synonym More Synonyms

 swainsonine Biological Activity

Description Swainsonine is an alkaloid isolated from Astragalus, acts as an inhibitor of α-mannosidase, with anti-tumor activity[1].
Related Catalog
References

[1]. Silveira CRF, et al. Swainsonine, an alpha-mannosidase inhibitor, may worsen cervical cancer progression through the increase in myeloid derived suppressor cells population. PLoS One. 2019 Mar 6;14(3):e0213184.

 Chemical & Physical Properties

Density 1.38±0.1 g/cm3
Boiling Point 353.3±21.0 °C at 760 mmHg
Melting Point 144-145 ºC
Molecular Formula C8H15NO3
Molecular Weight 173.210
Flash Point 209.7±20.7 °C
Exact Mass 173.105194
PSA 63.93000
LogP -0.79
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.609
Storage condition 2-8°C
Water Solubility Freely soluble (170 g/L) (25 ºC)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H312-H332
Precautionary Statements P280
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xn: Harmful;
Risk Phrases R20/21/22
Safety Phrases 36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS NM2408666
HS Code 29339900

 Synthetic Route

 Articles37

More Articles
Production, HPLC analysis, and in situ apoptotic activities of swainsonine toward lepidopteran, Sf-21 cell line.

Biotechnol. Prog. 30(5) , 1196-205, (2014)

Swainsonine, a secondary metabolite from Metarhizium anisopliae has been extensively studied in the complementary areas of therapeutics and toxicology. This work aims to develop a simple UV-HPLC metho...

DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.

Nucleic Acids Res. 39 , D1035-41., (2011)

DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, ...

Swainsonine inhibits growth and potentiates the cytotoxic effect of paclitaxel in hepatocellular carcinoma in vitro and in vivo.

Oncol. Rep. 28(6) , 2091-100, (2012)

Swainsonine, an extract from Astragalus membranaceus, exhibits broad inhibition of growth and pro-apoptotic activity in a number of tumor types. However, the underlying mechanism involved remains uncl...

 Synonyms

D-Swainsonine
(1S,2R,8R,8aR)-Octahydroindolizine-1,2,8-triol
(1S,2R,8R,8aR)-Octahydro-1,2,8-indolizinetriol
1,2,8-Indolizinetriol, octahydro-, (1S,2R,8R,8aR)-
8A,B-INDOLIZIDINE-1,2A,8B-TRIOL
Tridolgosir
SwainMoia
UNII-RSY4RK37KQ
swainsonine synthetic
Swainsonine
MFCD00017554
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