Guanine

Modify Date: 2024-01-02 17:57:39

Guanine Structure
Guanine structure
Common Name Guanine
CAS Number 73-40-5 Molecular Weight 151.126
Density 2.2±0.1 g/cm3 Boiling Point 561.5±42.0 °C at 760 mmHg
Molecular Formula C5H5N5O Melting Point >300 °C(lit.)
MSDS Chinese USA Flash Point 293.4±27.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of Guanine


Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.

 Names

Name Guanine
Synonym More Synonyms

 Guanine Biological Activity

Description Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds.
Related Catalog

 Chemical & Physical Properties

Density 2.2±0.1 g/cm3
Boiling Point 561.5±42.0 °C at 760 mmHg
Melting Point >300 °C(lit.)
Molecular Formula C5H5N5O
Molecular Weight 151.126
Flash Point 293.4±27.9 °C
Exact Mass 151.049408
PSA 100.45000
LogP -2.03
Vapour Pressure 0.0±1.6 mmHg at 25°C
Index of Refraction 2.047
Storage condition 2-8°C
Stability Stable. Incompatible with strong oxidizing agents.
Water Solubility practically insoluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MF8260000
CHEMICAL NAME :
Guanine
CAS REGISTRY NUMBER :
73-40-5
LAST UPDATED :
199709
DATA ITEMS CITED :
9
MOLECULAR FORMULA :
C5-H5-N5-O
MOLECULAR WEIGHT :
151.15
WISWESSER LINE NOTATION :
T56 BM DN FVM INJ HZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>3333 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg/26W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Reproductive - Tumorigenic effects - ovarian tumors

MUTATION DATA

TEST SYSTEM :
Rodent - mouse
DOSE/DURATION :
15 mg/kg
REFERENCE :
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958- Volume(issue)/page/year: 19,40,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2576 No. of Facilities: 1778 (estimated) No. of Industries: 3 No. of Occupations: 3 No. of Employees: 4133 (estimated) No. of Female Employees: 3339 (estimated)

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36-S37/39
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS MF8260000

 Synthetic Route

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 Synonyms

MFCD00071533
dewpearl
Guanin
2-amino-Hypoxanthine
9H-purin-6-ol, 2-amino-
2-amino-3,7-dihydro-6H-purin-6-one
7H-Purin-6-ol, 2-amino-
Guanine
2-amino-9H-purin-6-ol
Guanie
2-amino-6-oxypurine
Gua
guamine
EINECS 200-799-8
2-amino-1,7-dihydro-6H-purin-6-one
2-amino-1,9-dihydro-6H-purin-6-one
quanine
2-amino-6-hydroxypurine
Ganciclovir Impurity 6
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