Eicosapentaenoic Acid sodium
Modify Date: 2024-01-10 14:18:17
Eicosapentaenoic Acid sodium structure
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Common Name | Eicosapentaenoic Acid sodium | ||
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| CAS Number | 73167-03-0 | Molecular Weight | 324.43300 | |
| Density | 0.943 g/mL at 25ºC(lit.) | Boiling Point | 439.3ºC at 760 mmHg | |
| Molecular Formula | C20H29NaO2 | Melting Point | -54--53ºC(lit.) | |
| MSDS | Chinese USA | Flash Point | 336ºC | |
Use of Eicosapentaenoic Acid sodiumEicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3]. |
| Name | epa |
|---|---|
| Synonym | More Synonyms |
| Description | Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3]. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) sodium treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1]. Eicosapentaenoic Acid (100 µM; 1, 3, 24 h) sodium causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid sodium[1]. |
| References |
| Density | 0.943 g/mL at 25ºC(lit.) |
|---|---|
| Boiling Point | 439.3ºC at 760 mmHg |
| Melting Point | -54--53ºC(lit.) |
| Molecular Formula | C20H29NaO2 |
| Molecular Weight | 324.43300 |
| Flash Point | 336ºC |
| Exact Mass | 324.20700 |
| PSA | 40.13000 |
| LogP | 4.65800 |
| Appearance of Characters | waxy solid | white |
| Index of Refraction | n20/D 1.4977(lit.) |
| Storage condition | −20°C |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | C: Corrosive; |
| Risk Phrases | R34 |
| Safety Phrases | 26-36/37/39-45 |
| RIDADR | UN 3265 8/PG 3 |
| WGK Germany | 3 |
| MFCD00079184 |