DC Chemicals Limited
China
Product Name: Eicosapentaenoic Acid sodium
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

73167-03-0

73167-03-0 structure

Name: Eicosapentaenoic Acid sodium
Chemical Name: epa
CAS Number: 73167-03-0
Molecular Formula: C₂₀H₂₉NaO₂
Molecular Weight: 324.43300
Catalog: analytical chemistry food safety Fatty acid, fatty acid methyl ester
Create Date: 2018-12-23 19:25:07
Modify Date: 2024-01-10 14:18:17
Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].

Name	epa
Synonyms	MFCD00079184

Description	Eicosapentaenoic Acid (EPA)sodium is an orally active Omega-3 long-chain polyunsaturated fatty acid (ω-3 LC-PUFA). Eicosapentaenoic Acid sodium exhibits a DNA demethylating action that promotes the re-expression of the tumor suppressor gene CCAAT/enhancer-binding protein δ (C/EBPδ). Eicosapentaenoic Acid sodium activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. Eicosapentaenoic Acid sodium can promote relaxation of vascular smooth muscle cells and vasodilation[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> Epigenetics >> Histone Demethylase Research Areas >> Metabolic Disease
Target	Human Endogenous Metabolite
In Vitro	C/EBPβ phosphorylated form is evident in Eicosapentaenoic Acid (EPA; 100 µM; 24 h) sodium treated cells, whereas it was barely detectable in control, and OA or LA treated U937[1]. Eicosapentaenoic Acid (100 µM; 1, 3, 24 h) sodium causes a significant increase of H-Ras and N-Ras mRNA levels conditioning for 1 and 3 hours. K-Ras mRNA levels were not affected by Eicosapentaenoic Acid sodium[1].
References	[1]. Veronica Ceccarelli, et al. Eicosapentaenoic acid activates RAS/ERK/C/EBPβ pathway through H-Ras intron 1 CpG island demethylation in U937 leukemia cells. PLoS One. 2014 Jan 13;9(1):e85025. [2]. Miaozhen Pan, et al. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021 Oct 26;118(43):e2104689118. [3]. Shun-he Wang, et al. Endogenous omega-3 long-chain fatty acid biosynthesis from alpha-linolenic acid is affected by substrate levels, gene expression, and product inhibition. RSC Adv., 2017, 7, 40946-40951.

Density	0.943 g/mL at 25ºC(lit.)
Boiling Point	439.3ºC at 760 mmHg
Melting Point	-54--53ºC(lit.)
Molecular Formula	C₂₀H₂₉NaO₂
Molecular Weight	324.43300
Flash Point	336ºC
Exact Mass	324.20700
PSA	40.13000
LogP	4.65800
Appearance	waxy solid \| white
Index of Refraction	n20/D 1.4977(lit.)
Storage condition	−20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	C: Corrosive;
Risk Phrases	R34
Safety Phrases	26-36/37/39-45
RIDADR	UN 3265 8/PG 3
WGK Germany	3

73167-03-0	2734-47-6
73310-10-8	1392217-44-5
86227-47-6	32839-30-8
1197205-73-4	10417-94-4
117396-78-8	84494-70-2