Florfenicol

Modify Date: 2024-01-02 09:21:57

Florfenicol Structure
Florfenicol structure
 Common Name Florfenicol
CAS Number 73231-34-2 Molecular Weight 358.213
Density 1.5±0.1 g/cm3 Boiling Point 617.5±55.0 °C at 760 mmHg
Molecular Formula C12H14Cl2FNO4S Melting Point 153 °C
MSDS Chinese USA Flash Point 327.3±31.5 °C

 Use of Florfenicol


Florfenicol, a commonly used veterinary antibiotic, is currently indicated for the treatment of bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.

 Names

Name florfenicol
Synonym More Synonyms

 Florfenicol Biological Activity

Description Florfenicol, a commonly used veterinary antibiotic, is currently indicated for the treatment of bovine respiratory disease, and also used in aquaculture for the control of enteric septicemia in catfish. Florfenicol can induce early embryonic death in eggs, with an LC50 of 1.07 μg/g.
Related Catalog
References

[1]. Al-Shahrani S, et al. Florfenicol induces early embryonic death in eggs collected from treated hens. BMC Vet Res. 2015 Aug 18;11(1):213.

[2]. Corinna Kehrenberg, et al. A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Molecular Microbiology Volume 57, Issue 4, pages 1064–1073, August 2005

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 617.5±55.0 °C at 760 mmHg
Melting Point 153 °C
Molecular Formula C12H14Cl2FNO4S
Molecular Weight 358.213
Flash Point 327.3±31.5 °C
Exact Mass 357.000458
PSA 91.85000
LogP -0.12
Vapour Pressure 0.0±1.9 mmHg at 25°C
Index of Refraction 1.548
Storage condition 0-6°C

 MSDS

Material Safety Data Sheet
Section1. Identification of the substance
Product Name: Florfenicol
Synonyms:
Section2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.
Section3. Composition/information on ingredients.
Ingredient name:Florfenicol
CAS number:73231-34-2
Section4. First aid measures
Skin contact:Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact:Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation:Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion:Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.
Section5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.
Section6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution:Wear approved mask/respirator
Hand precaution:Wear suitable gloves/gauntlets
Skin protection:Wear suitable protective clothing
Eye protection:Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.
Section7. Handling and storage
Handling:This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:
Section8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.
Section9. Physical and chemical properties
Appearance:Not specified
Boiling point:No data
No data
Melting point:
Flash point:No data
Density:No data
Molecular formula:C12H14Cl2FNO4S
Molecular weight:358.2
Section10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides, hydrogen chloride, hydrogen fluoride, sulfur
oxides.
Section11. Toxicological information
No data.
Section12. Ecological information
No data.
Section13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.
Section14. Transportation information
Non-harzardous for air and ground transportation.
Section15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

SECTION 16 - ADDITIONAL INFORMATION
N/A

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DB6034000
CHEMICAL NAME :
Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl )-, methyl ester, (R-(R*,S*))-
CAS REGISTRY NUMBER :
73231-34-2
LAST UPDATED :
198806
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H11-Cl2-F-N2-O4
MOLECULAR WEIGHT :
325.14
WISWESSER LINE NOTATION :
WNR DYQY1FMVYGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,172,1982

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2930909090

 Synthetic Route

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

Florfenicol
2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methanesulfonyl)phenyl]ethyl]acetamide
NUFLOR
2,2-dichloro-N-[(1S
AQUAFEN
Fluorothiamphenicol
2,2-DIBROMODECAFLUOROPENTANE
2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
Florfeniol
Aquaflor
MFCD00864834
EINECS 642-986-0
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Chemsrc provides Florfenicol(CAS#:73231-34-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Florfenicol are included as well.>> amp version: Florfenicol

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