N-Methylcolchicine

Modify Date: 2024-01-10 18:20:38

N-Methylcolchicine structure	Common Name	N-Methylcolchicine
	CAS Number	7336-40-5	Molecular Weight	260.29
	Density	1.24g/cm3	Boiling Point	683.2ºC at 760 mmHg
	Molecular Formula	C₁₅H₁₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	367ºC

Use of N-Methylcolchicine

Micromarin F (compound 9) is synthesized from osthole. Micromarin F against Balanus albicostatus and Bugula neritina with EC50 values of 10.93 and 12.38 μM[1].

Name	N-methyl-N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide
Synonym	More Synonyms

Description	Micromarin F (compound 9) is synthesized from osthole. Micromarin F against Balanus albicostatus and Bugula neritina with EC50 values of 10.93 and 12.38 μM[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Zhan-Chang Wang, et al. Coumarins from the Herb Cnidium monnieri and Chemically Modified Derivatives as Antifoulants against Balanus albicostatus and Bugula neritina Larvae. Int. J. Mol. Sci. 2013, 14.

Density	1.24g/cm3
Boiling Point	683.2ºC at 760 mmHg
Molecular Formula	C₁₅H₁₆O₄
Molecular Weight	260.29
Flash Point	367ºC
Exact Mass	413.18400
PSA	74.30000
LogP	3.21380
Index of Refraction	1.583

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GH0890000

CHEMICAL NAME :: Colchicine, N-methyl-

CAS REGISTRY NUMBER :: 7336-40-5

BEILSTEIN REFERENCE NO. :: 2825013

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H27-N-O6

MOLECULAR WEIGHT :: 413.51

WISWESSER LINE NOTATION :: L B677 MV&T&J CO1 DO1 EO1 JN1&V1 NO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3400 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2900 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea

REFERENCE :: PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1445 ug/kg

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,257,1981

Hazard Codes	Xi

(-)-Demecolcine

CAS#:477-30-5

Ethanoic anhydride

CAS#:108-24-7

~95%

N-Methylcolchicine

CAS#:7336-40-5

Literature: Hufford; Capraro; Brossi Helvetica Chimica Acta, 1980 , vol. 63, # 1 p. 50 - 56

(7S)-2-hydroxy-...

CAS#:7359-91-3

N-Methylcolchicine

CAS#:7336-40-5

Literature: Santavy Collection of Czechoslovak Chemical Communications, 1959 , vol. 24, p. 2237,2242

diazomethane

CAS#:186581-53-3

N-Methylcolchicine

CAS#:7336-40-5

Literature: Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

diazomethane

CAS#:186581-53-3

N-Methylisocolc...

CAS#:7404-91-3

N-Methylcolchicine

CAS#:7336-40-5

Literature: Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

Methanol

CAS#:67-56-1

Colchiceine

CAS#:477-27-0

Sodium Methylate

CAS#:124-41-4

methyl iodide

CAS#:74-88-4

Detail

Literature: Uffer et al. Helvetica Chimica Acta, 1954 , vol. 37, p. 18,29

Precursor 8
CAS#:477-30-5 (-)-Demecolcine CAS#:108-24-7 Ethanoic anhydride CAS#:7359-91-3 (7S)-2-hydroxy-... CAS#:186581-53-3 diazomethane
CAS#:67-56-1 Methanol CAS#:477-27-0 Colchiceine CAS#:124-41-4 Sodium Methylate CAS#:74-88-4 methyl iodide
DownStream 0

N-Methylcolchicine

COLCHICINE,N-METHYL

Desacetylamino-N-methylcolchiceinamid

N-Acetyldemecolcine

N-methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamide

N-acetyldemecoline

N-Methyl-N-((S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydro-benzo[a]heptalen-7-yl)-acetamid

N-Methyl-colchicin

N-Acetylcolchamine

Acetamide,N-methyl-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)

N-Acetylcolcemid

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Colchicine, N-methyl-
Price: Click To Check
Purity: 98.0%
Delivery: 10 Day
Contact: Yang
Email: sales@echemcloud.com

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Acetamide,N-methyl-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Delivery: Inquiry
Contact: Ms Wang
Email: enquiry@dycnchem.com

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