L-arginine

Modify Date: 2024-01-02 18:24:40

L-arginine Structure
L-arginine structure
 Common Name L-arginine
CAS Number 74-79-3 Molecular Weight 174.201
Density 1.5±0.1 g/cm3 Boiling Point 367.6±52.0 °C at 760 mmHg
Molecular Formula C6H14N4O2 Melting Point 222 °C (dec.)(lit.)
MSDS Chinese USA Flash Point 176.1±30.7 °C

 Use of L-arginine


L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.

 Names

Name L-arginine
Synonym More Synonyms

 L-arginine Biological Activity

Description L-Arginine is the nitrogen donor for synthesis of nitric oxide, a potent vasodilator that is deficient during times of sickle cell crisis.Target: OthersL-Arginine is an α-amino acid. It was first isolated in 1886. The L-form is one of the 20 most common natural amino acids. At the level of molecular genetics, in the structure of the messenger ribonucleic acid mRNA, CGU, CGC, CGA, CGG, AGA, and AGG, are the triplets of nucleotide bases or codons that code for arginine during protein synthesis. In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual.L-Arginine is associated with a decrease in cardiac index while stroke index is maintained in patients with severe sepsis. Resolution of shock at 72 hours is achieved by 40% and 24% of the patients in the L-Arginine and placebo cohorts, respectively. L-Arginine (450 mg/kg during a 15-minute period) amplifies and sustains the hyperemia (38%) and increases absolute brain blood flow after eNOS upregulation by chronic simvastatin treatment (2 mg/kg subcutaneously, daily for 14 days) in SV-129 mice.
Related Catalog
Target

Human Endogenous Metabolite

References

[1]. Tapiero H, et al. I. Arginine. Biomed Pharmacother. 2002 Nov;56(9):439-45.

[2]. Bakker J, et al. Administration of the nitric oxide synthase inhibitor NG-methyl-L-arginine hydrochloride (546C88) by intravenous infusion for up to 72 hours can promote the resolution of shock in patients with severe sepsis: results of a randomized, double-blind, placebo-controlled multicenter study (study no. 144-002). Crit Care Med. 2004 Jan;32(1):1-12.

[3]. Yamada M, et al. Endothelial nitric oxide synthase-dependent cerebral blood flow augmentation by L-arginine after chronic statin treatment. J Cereb Blood Flow Metab. 2000 Apr;20(4):709-17.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 367.6±52.0 °C at 760 mmHg
Melting Point 222 °C (dec.)(lit.)
Molecular Formula C6H14N4O2
Molecular Weight 174.201
Flash Point 176.1±30.7 °C
Exact Mass 174.111679
PSA 125.22000
LogP -1.79
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.601
Water Solubility 148.7 g/L (20 ºC)

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CF1934200
CHEMICAL NAME :
Arginine, L-
CAS REGISTRY NUMBER :
74-79-3
BEILSTEIN REFERENCE NO. :
1725413
LAST UPDATED :
199710
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C6-H14-N4-O2
MOLECULAR WEIGHT :
174.24

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Cytogenetic analysis

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
10 mg/L
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 10 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3074 No. of Facilities: 685 (estimated) No. of Industries: 3 No. of Occupations: 14 No. of Employees: 19298 (estimated) No. of Female Employees: 15719 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xn: Harmful;
Risk Phrases R36
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS CF1934200
HS Code 2922499990

 Synthetic Route

 Customs

HS Code 2925290090
Summary 2925290090 other imines and their derivatives; salts thereof。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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 Synonyms

L-Arginine
L-ornithine, N-(diaminomethylene)-
MFCD00002635
H-L-ARG-OH
L-Argnie
(L)-Arginine
L-ARG-OH
L-arginie
AGRININE
arginine
L(+)-Arginine
L-Arginine (9CI)
QVYZ3MYZUM &&L or S Form
FEMA 3819
Pentanoic acid, 2-amino-5-[(aminoiminomethyl)amino]-, (S)-
EINECS 200-811-1
ARGININE, L-
L-a-Amino-d-guanidinovaleric Acid
L-Norvaline, 5-[(aminoiminomethyl)amino]-
(2S)-2-Amino-5-carbamimidamidopentanoic acid
H-ARG-OH
S-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid
l-arginin
Arginine, L- (8CI)
Arginine (VAN)
l-arg
5-[(Aminoiminomethyl)amino]-L-norvaline
Arg
N5-(Aminoiminomethyl)-L-ornithine
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Chemsrc provides L-arginine(CAS#:74-79-3) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of L-arginine are included as well.>> amp version: L-arginine

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