tert-Butyl Hydroperoxide

Modify Date: 2024-01-02 13:54:20

tert-Butyl Hydroperoxide structure	Common Name	tert-Butyl Hydroperoxide
	CAS Number	75-91-2	Molecular Weight	90.121
	Density	0.9±0.1 g/cm3	Boiling Point	120.4±9.0 °C at 760 mmHg
	Molecular Formula	C₄H₁₀O₂	Melting Point	-2.8 °C
	MSDS	Chinese USA	Flash Point	35.0±0.0 °C
	Symbol	GHS02, GHS05, GHS06, GHS08, GHS09	Signal Word	Danger

Name	tert-butyl hydroperoxide
Synonym	More Synonyms

Density	0.9±0.1 g/cm3
Boiling Point	120.4±9.0 °C at 760 mmHg
Melting Point	-2.8 °C
Molecular Formula	C₄H₁₀O₂
Molecular Weight	90.121
Flash Point	35.0±0.0 °C
Exact Mass	90.068077
PSA	29.46000
LogP	1.38
Vapour Pressure	7.4±0.5 mmHg at 25°C
Index of Refraction	1.399
Stability	Stable, but may explode if heated under confinement. Decomposition may be accelerated by traces of metals, molecular sieve or other contaminants. Incompatible with reducing agents, combustible material, acids.
Water Solubility	Miscible

tert-Butyl Hydroperoxide MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EQ4900000

CHEMICAL NAME :: tert-Butylhydroperoxide

CAS REGISTRY NUMBER :: 75-91-2

BEILSTEIN REFERENCE NO. :: 1098280

LAST UPDATED :: 199806

DATA ITEMS CITED :: 38

MOLECULAR FORMULA :: C4-H10-O2

MOLECULAR WEIGHT :: 90.14

WISWESSER LINE NOTATION :: QOX1&1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: Rinsed with water

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 370 mg/kg

TOXIC EFFECTS :: Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 500 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 790 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 87 mg/kg

TOXIC EFFECTS :: Behavioral - muscle weakness Behavioral - ataxia

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Behavioral - irritability Gastrointestinal - alteration in gastric secretion Blood - hemorrhage

TYPE OF TEST :: LC50 - Lethal concentration, 50 percent kill

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 350 ppm/4H

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 246 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 460 uL/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - cyanosis Liver - other changes Kidney, Ureter, Bladder - other changes in urine composition

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 107 mg/m3/17W-I

TOXIC EFFECTS :: Sense Organs and Special Senses (Olfaction) - change in sensation of smell Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in chlorine

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 365 mg/kg/7W-I

TOXIC EFFECTS :: Related to Chronic Data - death

TYPE OF TEST :: TCLo - Lowest published toxic concentration

ROUTE OF EXPOSURE :: Inhalation

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 107 mg/m3/17W-I

TOXIC EFFECTS :: Blood - changes in erythrocyte (RBC) count Nutritional and Gross Metabolic - weight loss or decreased weight gain

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Cytogenetic analysis

TYPE OF TEST :: Dominant lethal test

MUTATION DATA

TYPE OF TEST :: Sex chromosome loss and nondisjunction

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 34 umol/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 182,135,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-GERMANY JAN 1993 OEL-RUSSIA:STEL 5 mg/m3;Skin JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 14730 No. of Facilities: 75 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 433 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 14730 No. of Facilities: 266 (estimated) No. of Industries: 8 No. of Occupations: 14 No. of Employees: 12168 (estimated) No. of Female Employees: 4787 (estimated)

Symbol	GHS02, GHS05, GHS06, GHS08, GHS09
Signal Word	Danger
Hazard Statements	H226-H242-H302-H304-H311 + H331-H314-H317-H336-H341-H410
Precautionary Statements	P210-P234-P280-P301 + P310-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338-P331-P403 + P233
Personal Protective Equipment	Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes	C:Corrosive
Risk Phrases	R10;R20/21/22;R34;R43;R52/53;R7
Safety Phrases	S14-S3/7-S61-S45-S36/37/39-S24-S17-S16-S14A-S26-S62
RIDADR	UN 3109 5.2
WGK Germany	3
RTECS	EQ4900000
Packaging Group	II
Hazard Class	5.2

Precursor 9
CAS#:187939-68-0 1-tert-butylper... CAS#:75-28-5 Isobutane Resid... CAS#:75-34-3 Ethane, 1,1-dic... CAS#:67-97-0 Vitamin D3
CAS#:677-22-5 TERT-BUTYLMAGNE... CAS#:50-81-7 Ascorbic acid CAS#:3459-80-1 Benzyln-butylether CAS#:75-65-0 tert-Butanol
CAS#:3395-62-8 tert-butyl hydr...
DownStream 10
CAS#:109-13-7 tert-Butyl pero... CAS#:100-52-7 Benzaldehyde CAS#:67-64-1 Acetone CAS#:79-31-2 Isobutyric acid
CAS#:100-51-6 Benzyl alcohol CAS#:75-65-0 tert-Butanol CAS#:1421259-27-9 N-methyl-N-((1-... CAS#:105804-97-5 (N-methylanilin...
CAS#:52866-87-2 N-(tert-butylpe... CAS#:98-51-1 tbt

bFGF attenuates endoplasmic reticulum stress and mitochondrial injury on myocardial ischaemia/reperfusion via activation of PI3K/Akt/ERK1/2 pathway.

J. Cell. Mol. Med. 19(3) , 595-607, (2015)

Extensive research focused on finding effective strategies to prevent or improve recovery from myocardial ischaemia/reperfusion (I/R) injury. Basic fibroblast growth factor (bFGF) has been shown to ha...

Synthesis of PS/PO-chimeric oligonucleotides using mixed oxathiaphospholane and phosphoramidite chemistry.

Org. Biomol. Chem. 13(1) , 269-76, (2014)

Chimeric oligonucleotides containing phosphodiester and phosphorothioate linkages have been obtained using the solid phase synthesis. The oligonucleotide parts possessing natural internucleotide phosp...

Biocompatibility evaluation of porous ceria foams for orthopedic tissue engineering.

J. Biomed. Mater. Res. A 103(1) , 8-15, (2014)

Ceria ceramics have the unique ability to protect cells from free radical-induced damage, making them materials of interest for biomedical applications. To expand upon the understanding of the potenti...

2-hydroperoxy-2-methylpropane

MFCD00002130

EINECS 200-915-7

tert-Butyl hydroperoxide