Bovine adrenal medulla dodecapeptide

Modify Date: 2024-01-02 22:12:36

Bovine adrenal medulla dodecapeptide structure	Common Name	Bovine adrenal medulla dodecapeptide
	CAS Number	75513-71-2	Molecular Weight	1424.63000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₂H₉₇N₂₁O₁₆S	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Bovine adrenal medulla dodecapeptide

BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].

Name	bam-12p
Synonym	More Synonyms

Description	BAM-12P, an endogenous opioid peptide, is a novel pro-Met-enkephalin. BAM-12P can activate human κ-opioid receptor (hKOR) with an EC50 of 101 nM and a pEC50 of 6.99. BAM-12P is a ligand for CXCR7 with an EC50 of 175 nM[1][2][3].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> GPCR/G Protein >> CXCR Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Signaling Pathways >> Immunology/Inflammation >> CXCR Research Areas >> Neurological Disease
Target	human κ-opioid receptor (hKOR):101 nM (EC50) human κ-opioid receptor (hKOR):6.99 (pEC50) CXCR7:175 nM (EC50)
In Vitro	BAM-12P 在豚鼠回肠试验中显示出有效的阿片活性，IC50 为 15.5 nM[2]。
References	[1]. K Mizuno, et al. A new endogenous opioid peptide from bovine adrenal medulla: isolation and amino acid sequence of a dodecapeptide (BAM-12P). Biochem Biophys Res Commun. 1980 Aug 29;95(4):1482-8. [2]. Yuichi Ikeda, et al. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXCR7 signaling alters emotional behavior. Cell. 2013 Dec 5;155(6):1323-36. [3]. Eyal Vardy, et al. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Neuron. 2015 May 20;86(4):936-946.

Molecular Formula	C₆₂H₉₇N₂₁O₁₆S
Molecular Weight	1424.63000
Exact Mass	1423.71000
PSA	643.16000
LogP	2.50620
Storage condition	-20°C

Bovine adrenal medulla dodecapeptide MSDS(Chinese)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport
WGK Germany	3.0

Substrate specificity of a novel serine protease from soybean [Glycine max (L.) Merrill].

J. Biochem. 119(6) , 1094-9, (1996)

The substrate specificity of a novel serine protease isolated from soybean seeds, cultivar Keburi, was investigated using various peptide-MCAs and several neuropeptides involving single and paired bas...

Opioid activity of pro-enkephalin-derived peptides in mouse vas deferens and guinea pig ileum.

Neurosci. Lett. 61(3) , 267-71, (1985)

The inhibitory activity of several pro-enkephalin A-derived opioid peptides, containing the sequence of Met-enkephalin, was evaluated in two isolated organ preparations sensitive to opioids, the guine...

A new family of endogenous "big" Met-enkephalins from bovine adrenal medulla: purification and structure of docosa- (BAM-22P) and eicosapeptide (BAM-20P) with very potent opiate activity.

Biochem. Biophys. Res. Commun. 97 , 1283, (1980)