Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.

Modify Date: 2024-01-03 17:31:07

Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv. structure	Common Name	Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.
	CAS Number	76296-71-4	Molecular Weight	722.902
	Density	1.3±0.1 g/cm3	Boiling Point	849.1±65.0 °C at 760 mmHg
	Molecular Formula	C₃₉H₆₂O₁₂	Melting Point	189-192 °C
	MSDS	N/A	Flash Point	467.3±34.3 °C

Use of Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.

Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities[1][2].

Name	(3β,25R)-Spirost-5-en-3-yl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-g lucopyranoside
Synonym	More Synonyms

Description	Polyphyllin C (compound 2) is a spirostanol saponin. Polyphyllin C exhibits mild (IC50=36.87 µM) activities against the tyrosinase and moderate (IC50=1.59 µg/mL) antileishmanial activities[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Metabolic Enzyme/Protease >> Tyrosinase
Target	IC50: 36.87 µM (tyrosinase)[1]
References	[1]. Devkota KP, et, al. Tyrosinase inhibitory and antileishmanial constituents from the rhizomes of Paris polyphylla. Nat Prod Res. 2007 Apr;21(4):321-7. [2]. Singh SB, et, al. Spirostanol saponins from Paris polyphylla, structures of polyphyllin C, D, E and F. Phytochemistry.1980; 21(12): 2925-2929.

Density	1.3±0.1 g/cm3
Boiling Point	849.1±65.0 °C at 760 mmHg
Melting Point	189-192 °C
Molecular Formula	C₃₉H₆₂O₁₂
Molecular Weight	722.902
Flash Point	467.3±34.3 °C
Exact Mass	722.424133
PSA	176.76000
LogP	6.70
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.605

Hazard Codes	Xi

PolyphyllinC

(3β,25R)-Spirost-5-en-3-yl 3-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl 3-O-(6-deoxy-α-L-mannopyranosyl)-

Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.

Use of Spiro[8H-naphth[2',1':4,5]indeno[2,1-b]furan-8,2'-[2H]pyran] alpha-D-glucopyranoside deriv.

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