(RS)-AMPA monohydrate

Modify Date: 2024-01-08 17:33:07

(RS)-AMPA monohydrate structure	Common Name	(RS)-AMPA monohydrate
	CAS Number	76463-67-7	Molecular Weight	204.18
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₇H₁₂N₂O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of (RS)-AMPA monohydrate

(RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors[1][2].

Name	(RS)-AMPA monohydrate

Description	(RS)-AMPA ((±)-AMPA) monohydrate is a glutamate analogue and a potent and selective excitatory neurotransmitter L-glutamic acid agonist. (RS)-AMPA monohydrate does not interfere with binding sites for kainic acid or NMDA receptors[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	(RS)-AMPA monohydrate (10-3-10-4 M) causes depolarizations of cultured rat spinal and brainstem neurones. The depolarization by (RS)-AMPA monohydrate is clearly dose-dependent, although there is a great variability of effects between individual neurones. Application of (RS)-AMPA monohydrate at 10-5 M produces only small depolarizations (3-7 mV), whereas at 10-4 M, the amplitudes of the depolarizations ranged from 4 to 33 mV. (RS)-AMPA monohydrate also causes an increase of the discharge rate of spontaneously firing neurones or sometimes evoked a short burst of action potentials in silent cells. (RS)-AMPA monohydrate exerts its depolarizing effects by activating glutamate/quisqualate receptors without affecting NMDA receptors[1].
References	[1]. Hösli L, et al. Effects of the glutamate analogue AMPA and its interaction with antagonists on cultured rat spinal and brain stem neurones. Neurosci Lett. 1983 Mar 28;36(1):59-62. [2]. Sommer B, et al. Flip and flop: a cell-specific functional switch in glutamate-operated channels of the CNS. Science. 1990 Sep 28;249(4976):1580-5.

Molecular Formula	C₇H₁₂N₂O₅
Molecular Weight	204.18

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: (RS)-AMPA monohydrate
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

DC Chemicals Limited
China
Product Name: (RS)-AMPA monohydrate
Price: ￥Inquiry/1g
Purity: 98.9%
Delivery: 1 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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Price: ￥3300/10 mM * 1 mL in DMSO

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(RS)-AMPA monohydrate

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(RS)-AMPA monohydrate Biological Activity

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