PTP1B-IN-4
Modify Date: 2024-01-07 21:00:44
PTP1B-IN-4 structure
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Common Name | PTP1B-IN-4 | ||
|---|---|---|---|---|
| CAS Number | 765317-72-4 | Molecular Weight | 741.448 | |
| Density | 1.8±0.1 g/cm3 | Boiling Point | 855.0±75.0 °C at 760 mmHg | |
| Molecular Formula | C26H19Br2N3O7S3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 470.9±37.1 °C | |
Use of PTP1B-IN-4PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2]. |
| Name | 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide |
|---|---|
| Synonym | More Synonyms |
| Description | PTP1B-IN-4 is a non-competitive allosteric inhibitor of the protein tyrosine phosphatase PTP1B, with an IC50 of 8 μM. PTP1B-IN-4 is potentail for the research of obesity and diabetes[1][2]. |
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| Related Catalog | |
| Target |
IC50: 8 μM (PTP1B)[1] |
| In Vitro | PTP1B-IN-4 (250 µM; 1 hour) stimulates insulin receptor (IR) phosphorylation in CHO cells overexpressing human IR[1]. PTP1B-IN-4 also induces phosphorylation of IRS-1 and Akt, proteins downstream of the insulin receptor[1]. Western Blot Analysis[1] Cell Line: CHO cells Concentration: 250 µM Incubation Time: 1 hour Result: Stimulated insulin receptor phosphorylation. |
| References |
| Density | 1.8±0.1 g/cm3 |
|---|---|
| Boiling Point | 855.0±75.0 °C at 760 mmHg |
| Molecular Formula | C26H19Br2N3O7S3 |
| Molecular Weight | 741.448 |
| Flash Point | 470.9±37.1 °C |
| Exact Mass | 738.875183 |
| PSA | 200.67000 |
| LogP | 6.80 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.727 |
| 3-(3,5-Dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]-1-benzofuran-6-sulfonamide |
| 1t4j |
| 6-Benzofuransulfonamide, 3-(3,5-dibromo-4-hydroxybenzoyl)-2-ethyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]- |
| PTP1B Inhibitor |
| FRJ |