Cathepsin B inhibitor RC1

Modify Date: 2023-01-12 00:39:47

Cathepsin B inhibitor RC1 Structure
Cathepsin B inhibitor RC1 structure
Common Name Cathepsin B inhibitor RC1
CAS Number 775573-79-0 Molecular Weight 325.537
Density N/A Boiling Point N/A
Molecular Formula C20H39NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Cathepsin B inhibitor RC1


Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes; protects host cells independently of LT concentration and also blocks intoxication by other bacterial exotoxins; reduces the pathogenicity of Human cytomegalovirus and HSV-1 (EC50=12 uM), which relies on cathepsin B protease activity.

 Names

Name Cathepsin B inhibitor RC1

 Cathepsin B inhibitor RC1 Biological Activity

Description Cathepsin B inhibitor RC1 is a small-molecule that blocks the process of anthrax lethal toxin (LT) cytotoxicity, inhibits enzymatic activity of host cathepsin B that mediates the escape of toxins into the cytoplasm from late endosomes; protects host cells independently of LT concentration and also blocks intoxication by other bacterial exotoxins; reduces the pathogenicity of Human cytomegalovirus and HSV-1 (EC50=12 uM), which relies on cathepsin B protease activity.
References References 1. Hartmann S, et al. ACS Infect Dis. 2018 May 18. doi: 10.1021/acsinfecdis.8b00053. 2. Gillespie EJ, et al. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. View Related Products by Target Cathepsin

 Chemical & Physical Properties

Molecular Formula C20H39NO2
Molecular Weight 325.537
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