1,2-Dihydrotanshinquinone

Modify Date: 2024-01-04 23:30:49

1,2-Dihydrotanshinquinone Structure
1,2-Dihydrotanshinquinone structure
 Common Name 1,2-Dihydrotanshinquinone
CAS Number 77769-21-2 Molecular Weight 278.302
Density 1.3±0.1 g/cm3 Boiling Point 495.6±44.0 °C at 760 mmHg
Molecular Formula C18H14O3 Melting Point N/A
MSDS N/A Flash Point 244.6±21.1 °C

 Use of 1,2-Dihydrotanshinquinone


1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].

 Names

Name 1,6-Dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione
Synonym More Synonyms

 1,2-Dihydrotanshinquinone Biological Activity

Description 1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].
Related Catalog
In Vitro 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1) (≥50% inhibition at 100 µg/mL)[1].
References

[1]. Faleschini MT, et, al. Discovery of natural products potentially active against myotonic dystrophy type 1. Planta Med 2015; 81-YRW_03.

[2]. Fronza M, et, al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011 Aug 15;19(16):4876-81.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 495.6±44.0 °C at 760 mmHg
Molecular Formula C18H14O3
Molecular Weight 278.302
Flash Point 244.6±21.1 °C
Exact Mass 278.094299
LogP 4.55
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.629

 Synonyms

Phenanthro(1,2-b)furan-10,11-dione, 8,9-dihydro-1,6-dimethyl-
1,6-Dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione
Phenanthro[1,2-b]furan-10,11-dione, 8,9-dihydro-1,6-dimethyl-
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