77769-21-2

77769-21-2 structure

Name: 1,2-Dihydrotanshinquinone
Chemical Name: 1,6-Dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione
CAS Number: 77769-21-2
Molecular Formula: C₁₈H₁₄O₃
Molecular Weight: 278.302
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-06-10 21:42:55
Modify Date: 2024-01-04 23:30:49
1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].

Name	1,6-Dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione
Synonyms	Phenanthro(1,2-b)furan-10,11-dione, 8,9-dihydro-1,6-dimethyl- 1,6-Dimethyl-8,9-dihydrophenanthro[1,2-b]furan-10,11-dione Phenanthro[1,2-b]furan-10,11-dione, 8,9-dihydro-1,6-dimethyl-

Description	1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology
In Vitro	1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1) (≥50% inhibition at 100 µg/mL)[1].
References	[1]. Faleschini MT, et, al. Discovery of natural products potentially active against myotonic dystrophy type 1. Planta Med 2015; 81-YRW_03. [2]. Fronza M, et, al. In vitro cytotoxic activity of abietane diterpenes from Peltodon longipes as well as Salvia miltiorrhiza and Salvia sahendica. Bioorg Med Chem. 2011 Aug 15;19(16):4876-81.