N-Desethyl amodiaquine

Modify Date: 2024-01-05 10:14:21

N-Desethyl amodiaquine Structure
N-Desethyl amodiaquine structure
Common Name N-Desethyl amodiaquine
CAS Number 79352-78-6 Molecular Weight 327.81
Density 1.304g/cm3 Boiling Point 477.8ºC at 760 mmHg
Molecular Formula C18H18ClN3O Melting Point 168-174ºC
MSDS N/A Flash Point 242.7ºC

 Use of N-Desethyl amodiaquine


N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].

 Names

Name n-desethyl amodiaquine dihcl
Synonym More Synonyms

 N-Desethyl amodiaquine Biological Activity

Description N-Desethyl amodiaquine is the major biologically active metabolite of Amodiaquine. N-Desethyl amodiaquine is an antiparasitic agent. IC50 values for strains V1/S and 3D7 are 97 nM and 25 nM, respectively[1].
Related Catalog
References

[1]. Sasi P, et al. In vivo and in vitro efficacy of amodiaquine against Plasmodium falciparum in an area of continued use of 4-aminoquinolines in East Africa. J Infect Dis. 2009 Jun 1;199(11):1575-82.

 Chemical & Physical Properties

Density 1.304g/cm3
Boiling Point 477.8ºC at 760 mmHg
Melting Point 168-174ºC
Molecular Formula C18H18ClN3O
Molecular Weight 327.81
Flash Point 242.7ºC
Exact Mass 332.14500
PSA 57.18000
LogP 4.91080
Index of Refraction 1.69

 Synthetic Route

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N-Desethyl amodiaquine Structure

N-Desethyl amod...

CAS#:79352-78-6

Literature: European Journal of Clinical Pharmacology, , vol. 59, # 5-6 p. 429 - 442

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N-Desethyl amodiaquine Structure

N-Desethyl amod...

CAS#:79352-78-6

Literature: Journal of Medicinal Chemistry, , vol. 24, # 12 p. 1471 - 1475

 Synonyms

N-Desethylamodiaquine
4-[(7-Chloro-4-quinolinyl)aMino]-2-[(ethylaMino)Methyl]phenol
N-de-ethyl amodiaquine
Desethylamodiaquine-[2H5]
4-[(7-Chloro-4-quinolyl)amino]-2-aminomethylphenol
N-Desethylamodiaquine dihydrochloride
desethylamodiaquine
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