4-Methyl-4-(methyldisulfanyl)pentanoicacid

Modify Date: 2024-01-03 19:51:45

4-Methyl-4-(methyldisulfanyl)pentanoicacid Structure
4-Methyl-4-(methyldisulfanyl)pentanoicacid structure
Common Name 4-Methyl-4-(methyldisulfanyl)pentanoicacid
CAS Number 796073-55-7 Molecular Weight 194.31500
Density N/A Boiling Point N/A
Molecular Formula C7H14O2S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 4-Methyl-4-(methyldisulfanyl)pentanoicacid


4-Methyl-4-(methyldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

 Names

Name 4-methyl-4-(methyldisulfanyl)pentanoic acid
Synonym More Synonyms

  Biological Activity

Description 4-Methyl-4-(methyldisulfanyl)pentanoic acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog
Target

Cleavable

In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
References

[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

 Chemical & Physical Properties

Molecular Formula C7H14O2S2
Molecular Weight 194.31500
Exact Mass 194.04400
PSA 87.90000
LogP 2.64100

 Synthetic Route

~82%

4-Methyl-4-(methyldisulfanyl)pentanoicacid Structure

4-Methyl-4-(met...

CAS#:796073-55-7

Literature: Zhao, Robert Yongxin; Erickson, Hans K.; Leece, Barbara A.; Reid, Emily E.; Goldmacher, Victor S.; Lambert, John M.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2012 , vol. 55, # 2 p. 766 - 782

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4-Methyl-4-(methyldisulfanyl)pentanoicacid Structure

4-Methyl-4-(met...

CAS#:796073-55-7

Literature: Widdison, Wayne C.; Wilhelm, Sharon D.; Cavanagh, Emily E.; Whiteman, Kathleen R.; Leece, Barbara A.; Kovtun, Yelena; Goldmacher, Victor S.; Xie, Hongsheng; Steeves, Rita M.; Lutz, Robert J.; Zhao, Robert; Wang, Lintao; Blaettler, Walter A.; Chari, Ravi V. J. Journal of Medicinal Chemistry, 2006 , vol. 49, # 14 p. 4392 - 4408

 Precursor & DownStream

Precursor  2

DownStream  0

 Synonyms

4-methyl-4-(methyldithio)pentanoic acid
Pentanoic acid,4-methyl-4-(methyldithio)
4-methyl-4-methyldisulfanylpentanoic acid
4-methyldithio-4-methyl-pentanoic acid