2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-

Modify Date: 2024-01-11 17:30:52

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure
2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- structure
 Common Name 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-
CAS Number 81691-06-7 Molecular Weight 258.23
Density 1.576g/cm3 Boiling Point N/A
Molecular Formula C10H14N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-


3-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 3-methylpseudouridine

  Biological Activity

Description 3-Methyl-5-β-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedione is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.576g/cm3
Molecular Formula C10H14N2O6
Molecular Weight 258.23
Exact Mass 258.08500
PSA 124.78000
Index of Refraction 1.618

 Synthetic Route

3-methyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)pseudouridine structure

3-methyl-3',5'-...

CAS#:81691-07-8

~87%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854
3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)pseudouridine structure

3',5'-O-(1,1,3,...

CAS#:80545-49-9

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854
Pseudouridine structure

Pseudouridine

CAS#:1445-07-4

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854
N/A structure

N/A

CAS#:164300-60-1

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854
N/A structure

N/A

CAS#:482643-86-7

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854
N/A structure

N/A

CAS#:482643-84-5

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854
N/A structure

N/A

CAS#:482643-88-9

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Chui, Helen M-P; Desaulniers, Jean-Paul; Scaringe, Stephen A; Chow, Christine S The Journal of organic chemistry, 2002 , vol. 67, # 25 p. 8847 - 8854
1-acetyl-2',3',5'-tri-O-trimethylsilyl-ψ-uridine structure

1-acetyl-2',3',...

CAS#:81691-04-5

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Matsuda; Pankiewicz; Marcus; Watanabe; Fox Carbohydrate research, 1982 , vol. 100, p. 297 - 302
1-acetyl-5-((2S,3S,4R,5R)-3,4-bis((trimethylsilyl)oxy)-5-(((trimethylsilyl)oxy)methyl)tetrahydrofuran-2-yl)-3-methylpyrimidine-2,4(1H,3H)-dione structure

1-acetyl-5-((2S...

CAS#:81691-05-6

~%

2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl- Structure

2,4(1H,3H)-Pyri...

CAS#:81691-06-7

Literature: Matsuda; Pankiewicz; Marcus; Watanabe; Fox Carbohydrate research, 1982 , vol. 100, p. 297 - 302
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Chemsrc provides CAS#:81691-06-7 MSDS, density, melting point, boiling point, structure, etc. Its name is 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl->> amp version: 2,4(1H,3H)-Pyrimidinedione,3-methyl-5-b-D-ribofuranosyl-

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