PL-017

Modify Date: 2024-01-10 17:10:39

PL-017 structure	Common Name	PL-017
	CAS Number	83397-56-2	Molecular Weight	535.635
	Density	1.3±0.1 g/cm3	Boiling Point	878.5±65.0 °C at 760 mmHg
	Molecular Formula	C₂₉H₃₇N₅O₅	Melting Point	N/A
	MSDS	N/A	Flash Point	485.1±34.3 °C

Use of PL-017

PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats[1].

Name	pl017
Synonym	More Synonyms

Description	PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	IC50: 5.5 nM (125I-FK 33,824 binding to μ site)[1]
In Vitro	PL-017 has an IC50 of 10000 nM for 125I-DADLE binding to δ site[1].
In Vivo	PL-017 (0.22, 0.45, 0.9 nmol/rat; i.c.v.) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g[1].
References	[1]. K J Chang, et al. Potent morphiceptin analogs: structure activity relationships and morphine-like activities. J Pharmacol Exp Ther. 1983 Nov;227(2):403-8.

Density	1.3±0.1 g/cm3
Boiling Point	878.5±65.0 °C at 760 mmHg
Molecular Formula	C₂₉H₃₇N₅O₅
Molecular Weight	535.635
Flash Point	485.1±34.3 °C
Exact Mass	535.279480
PSA	150.27000
LogP	0.93
Vapour Pressure	0.0±0.3 mmHg at 25°C
Index of Refraction	1.630
Storage condition	-20°C

Safety Phrases	22-24/25

H-TYR-PRO-N-ME-PHE-D-PRO-NH2

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L-Prolinamide, L-tyrosyl-L-prolyl-N-methyl-L-phenylalanyl-

L-Tyrosyl-L-prolyl-N-methyl-L-phenylalanyl-L-prolinamide

L-Tyrosyl-L-prolyl-N-methyl-L-phenylalanyl-D-prolinamide

L-Tyr-L-Pro-N-Methyl-L-Phe-D-Pro-NH2

[NMePhe3, DPro4] b-Casomorphin: 1-4, amide, bovine

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: PL-017
Price: Negotiable
Purity: 98.0%
Delivery: 10 Day
Contact: Huang
Email: sales@echemcloud.com

GL Biochem (Shanghai) Ltd.
China
Product Name: [NMePhe3, DPro4] b-Casomorphin: 1-4, amide, bovine
Price: $Inquiry/1g
Purity: 98.0%
Delivery: Inquiry
Contact: Jackie Yang
Email: ymbetter@glbiochem.com

DC Chemicals Limited
China
Product Name: PL-017
Price: $Inquiry/250mg $Inquiry/100mg $Inquiry/1g
Purity: 98.0%
Delivery: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

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