83397-56-2
83397-56-2 structure
- Name: PL-017
- Chemical Name: pl017
- CAS Number: 83397-56-2
- Molecular Formula: C29H37N5O5
- Molecular Weight: 535.635
- Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
- Create Date: 2016-10-26 14:06:19
- Modify Date: 2024-01-10 17:10:39
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PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats[1].
| Name | pl017 |
|---|---|
| Synonyms |
H-TYR-PRO-N-ME-PHE-D-PRO-NH2
Cardiogenol C hydrochloride D-Prolinamide, L-tyrosyl-L-prolyl-N-methyl-L-phenylalanyl- L-Prolinamide, L-tyrosyl-L-prolyl-N-methyl-L-phenylalanyl- L-Tyrosyl-L-prolyl-N-methyl-L-phenylalanyl-L-prolinamide L-Tyrosyl-L-prolyl-N-methyl-L-phenylalanyl-D-prolinamide L-Tyr-L-Pro-N-Methyl-L-Phe-D-Pro-NH2 [NMePhe3, DPro4] b-Casomorphin: 1-4, amide, bovine |
| Description | PL-017 is a potent and selective μ opioid receptor agonist with an IC50 of 5.5 nM for 125I-FK 33,824 binding to μ site. PL-017 produces long-lasting, reversible analgesia in rats[1]. |
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| Related Catalog | |
| Target |
IC50: 5.5 nM (125I-FK 33,824 binding to μ site)[1] |
| In Vitro | PL-017 has an IC50 of 10000 nM for 125I-DADLE binding to δ site[1]. |
| In Vivo | PL-017 (0.22, 0.45, 0.9 nmol/rat; i.c.v.) has the time of maximum effect of approximately 15 to 30 mm after injection at lower doses and produces analgesia lasting as long as 4 hours with larger doses in male Sprague-Dawley rats weighing 250 to 375 g[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 878.5±65.0 °C at 760 mmHg |
| Molecular Formula | C29H37N5O5 |
| Molecular Weight | 535.635 |
| Flash Point | 485.1±34.3 °C |
| Exact Mass | 535.279480 |
| PSA | 150.27000 |
| LogP | 0.93 |
| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
| Index of Refraction | 1.630 |
| Storage condition | -20°C |
| Safety Phrases | 22-24/25 |
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