Trimeprazine

Modify Date: 2024-01-02 17:39:10

Trimeprazine Structure
Trimeprazine structure
Common Name Trimeprazine
CAS Number 84-96-8 Molecular Weight 298.44600
Density 1.203 g/cm3 Boiling Point 420.3ºC at 760mmHg
Molecular Formula C18H22N2S Melting Point 68°C
MSDS N/A Flash Point 208ºC

 Use of Trimeprazine


Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays sedative, antiserotonin, antispasmodic, and antiemetic properties[1][2].

 Names

Name N,N,2-trimethyl-3-phenothiazin-10-ylpropan-1-amine
Synonym More Synonyms

 Trimeprazine Biological Activity

Description Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays sedative, antiserotonin, antispasmodic, and antiemetic properties[1][2].
Related Catalog
Target

HA receptor[1]

References

[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

[2]. Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1(3).

 Chemical & Physical Properties

Density 1.203 g/cm3
Boiling Point 420.3ºC at 760mmHg
Melting Point 68°C
Molecular Formula C18H22N2S
Molecular Weight 298.44600
Flash Point 208ºC
Exact Mass 298.15000
PSA 31.78000
LogP 4.55200
Water Solubility 0.942 mg/L

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SO5700000
CHEMICAL NAME :
Phenothiazine, 10-(3-(dimethylamino)-2-methylpropyl)-
CAS REGISTRY NUMBER :
84-96-8
LAST UPDATED :
199512
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H22-N2-S
MOLECULAR WEIGHT :
298.48
WISWESSER LINE NOTATION :
T C666 BN ISJ B1Y1&1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
210 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ANPBAZ Acta Neurologia et Psychiatrica Belgica. (Brussels, Belgium) V.48-69, 1948-69. For publisher information, see ANUBBR. Volume(issue)/page/year: 61,669,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
300 mg/kg
TOXIC EFFECTS :
Behavioral - antipsychotic
REFERENCE :
DNEUD5 Developments in Neuroscience (Amsterdam). (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1977- Volume(issue)/page/year: 7,45,1980
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
33 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PSCBAY Psychopharmacology Service Center, Bulletin. (Bethesda, MD) V.1-3, 1961-65. For publisher information, see PSYBB9. Volume(issue)/page/year: 2,17,1963 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4969 No. of Facilities: 32 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 333 (estimated) No. of Female Employees: 227 (estimated)

 Synonyms

Methylpromazine
Isobutrazine
EINECS 201-577-3
Repetin
Alimemazine
N,N-dimethyl-N-<2-methyl-3-(10H-10-phenothiazinyl)propyl>amine
Alimezine
dl-Trimeprazine
Teralen
10-[3-(dimethylamino)-2-methylpropyl]phenothiazine
Trimeprazine
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