4330-99-8

4330-99-8 structure

Name: Alimemazine hemitartrate
Chemical Name: Alimemazine hemitartrate
CAS Number: 4330-99-8
Molecular Formula: C₁₈H₂₂N₂S_.1/₂C₄H₆O₆
Molecular Weight: 373.49
Catalog: Research Areas Inflammation/Immunology
Create Date: 2018-02-20 08:00:00
Modify Date: 2024-01-05 17:52:16
Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.

Name	Alimemazine hemitartrate
Synonyms	Trimeprazine Tartrate 10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine Tartrate 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 2,3-dihydroxybutanedioate (1:1) (salt) Alimemazine EINECS 224-368-9 N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine 2,3-dihydroxybutanedioate (1:1) N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine 2,3-dihydroxysuccinate (1:1) MFCD00242594

Description	Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease Research Areas >> Inflammation/Immunology
Target	HA receptor[1]
References	[1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64.

Melting Point	>300 °C(lit.)
Molecular Formula	C₁₈H₂₂N₂S_.1/₂C₄H₆O₆
Molecular Weight	373.49
PSA	178.62000
LogP	6.98140
Storage condition	Refrigerator

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO6475000

CAS REGISTRY NUMBER :: 4330-99-8

LAST UPDATED :: 199504

DATA ITEMS CITED :: 7

MOLECULAR FORMULA :: C36-H44-N4-S2.C4-H6-O6

MOLECULAR WEIGHT :: 747.06

WISWESSER LINE NOTATION :: T C666 BN ISJ B1Y1&1N1&1 &OVYQYQVO

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 210 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 110 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 35 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,41,1982

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 140 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 33 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5558 No. of Facilities: 137 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1472 (estimated) No. of Female Employees: 835 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	Missing Phrase - N15.00950417
Hazard Codes	Xn
Risk Phrases	20/21/22
Safety Phrases	S36
RIDADR	3249
RTECS	SO6475000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2934300000

HS Code	2934300000
Summary	2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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