Mafosfamide Sodium Salt
Modify Date: 2024-01-16 22:32:20
Mafosfamide Sodium Salt structure
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Common Name | Mafosfamide Sodium Salt | ||
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| CAS Number | 84211-05-2 | Molecular Weight | 401.26700 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C9H18Cl2N2NaO5PS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Mafosfamide Sodium SaltMafosfamide sodium salt (Z 7557 sodium salt) targets nuclear DNA, forms DNA cross-links and inhibits DNA synthesis. Mafosfamide sodium salt, a cyclophosphamide analogue, induces apoptosis in lymphoblastoid cells. Mafosfamide sodium salt has antitumor activity[1][2]. |
| Name | 2-({2-[Bis(2-chloroethyl)amino]-2-oxido-1,3,2-oxazaphosphinan-4-y l}sulfanyl)ethanesulfonic acid |
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| Description | Mafosfamide sodium salt (Z 7557 sodium salt) targets nuclear DNA, forms DNA cross-links and inhibits DNA synthesis. Mafosfamide sodium salt, a cyclophosphamide analogue, induces apoptosis in lymphoblastoid cells. Mafosfamide sodium salt has antitumor activity[1][2]. |
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| Related Catalog | |
| In Vitro | Mafosfamide sodium salt (Z 7557 sodium salt; 2-10 μg/ml; 72 hours) triggers apoptosis in a dose and time dependent manner[1]. Mafosfamide sodium salt (2-10 μg/ml; 24 hours) causes the cells accumulated in S-phase[1]. Mafosfamide sodium salt (10 μg/ml; 24-72 hours) causes p53 stabilization[1]. Mafosfamide sodium salt (10 μg/ml) induces transcriptional inhibition that contributes to the apoptotic response combined with α-amanitin[1]. Apoptosis Analysis[1] Cell Line: TK6 and WTK1 cells Concentration: 2, 10 μg/ml Incubation Time: 72 hours Result: Triggered apoptosis in a dose and time dependent manner. Preferentially induced apoptosis (> 70% of dead cells) in both p53wt and p53mt cells, with necrosis only induced at low levels (< 30% of dead cells). Cell Cycle Analysis[1] Cell Line: TK6 and WTK1 cells Concentration: 2, 10 μg/ml Incubation Time: 24 hours Result: The cells accumulated in S-phase. Western Blot Analysis[1] Cell Line: TK6 and WTK1 cells Concentration: 10 μg/ml Incubation Time: 24, 48, 72 hours Result: Caused p53 stabilization by phosphorylation of Ser15, 20 and 37, and activation of ATM/ATR and Chk1/Chk2. |
| References |
| Molecular Formula | C9H18Cl2N2NaO5PS2 |
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| Molecular Weight | 401.26700 |
| Exact Mass | 399.98500 |
| PSA | 139.43000 |
| LogP | 3.24070 |