Bedaquiline
Modify Date: 2024-01-02 20:31:53
Bedaquiline structure
|
Common Name | Bedaquiline | ||
|---|---|---|---|---|
| CAS Number | 843663-66-1 | Molecular Weight | 555.50 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 702.7±60.0 °C at 760 mmHg | |
| Molecular Formula | C32H31BrN2O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 378.8±32.9 °C | |
Use of BedaquilineBedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase. |
| Name | tmc-207 |
|---|---|
| Synonym | More Synonyms |
| Description | Bedaquiline is a diarylquinoline antibiotic that inhibits mycobacterial ATP synthase. |
|---|---|
| Related Catalog | |
| Target |
mycobacterial ATP synthase[1] |
| In Vitro | Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[1]. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[2]. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[3]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 702.7±60.0 °C at 760 mmHg |
| Molecular Formula | C32H31BrN2O2 |
| Molecular Weight | 555.50 |
| Flash Point | 378.8±32.9 °C |
| PSA | 36.36000 |
| LogP | 7.59 |
| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
| Index of Refraction | 1.666 |
| Storage condition | -20℃ |
CAS#:1229443-16-6
CAS#:124-40-3
CAS#:1298044-25-3
CAS#:1298044-31-1
CAS#:1298044-13-9| methyl 6-azanyl-2-benzamido-hexanoate hydrochloride |
| BZ-LYS-OME HCL |
| Sirturo |
| methyl (2S)-6-amino-2-benzamidohexanoate |
| Bedaquiline |
| 6-amino-2-benzamidohexanoic acid methyl ester hydrochloride |
| (1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol |
| 3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)- |
| (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol |
| TMC207 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: Bedaquiline
- Price: Click To Check
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Yang
- Email: sales@echemcloud.com
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Bedaquiline
- Price: ￥716.0/2mg ￥1736.0/10mg ￥6016.0/50mg ￥1126.0/5mg
- Purity: 99.0%
- Delivery: 1 Day
- Contact: Liu jia
- Email: 2130147988@qq.com
- DC Chemicals Limited
- China
- Product Name: Bedaquiline (TMC207)
- Price: $250.0/100mg $500.0/250mg $1000.0/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: Bedaquiline (TMC207)
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 6-Bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Delivery: Inquiry
- Contact: Ms Wang
- Email: enquiry@dycnchem.com
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Bedaquiline
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Delivery: Inquiry
- Contact: Anson
- Email: info@tianfuchem.com
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Price: $73/10mM*1mLinDMSO
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