Bedaquiline fumarate

Modify Date: 2024-01-02 13:09:56

Bedaquiline fumarate Structure
Bedaquiline fumarate structure
 Common Name Bedaquiline fumarate
CAS Number 845533-86-0 Molecular Weight 671.577
Density N/A Boiling Point N/A
Molecular Formula C36H35BrN2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Bedaquiline fumarate


Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.

 Names

Name (1R,2S)-1-(6-bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-naphthalen-1-yl-1-phenylbutan-2-ol,(E)-but-2-enedioic acid
Synonym More Synonyms

 Bedaquiline fumarate Biological Activity

Description Bedaquiline fumarate, a diarylquinoline antibiotic that targets ATP synthase, is effective for the treatment of Mycobacterium tuberculosis infections.
Related Catalog
In Vitro Bedaquiline inhibits the growth of TDR M. tuberculosis strains, with MIC values ranging from 0.125 to 0.5 mg/L[1]. Among slowly growing mycobacteria (SGM), bedaquiline exhibits the highest activity against Mycobacterium avium with MIC50 and MIC90 values of 0.03 and 16 mg/L, respectively. Among rapidly growing mycobacteria (RGM), Mycobacterium abscessus subsp. abscessus (M. abscessus) and Mycobacterium abscessus subsp. massiliense (M. massiliense) seem more susceptible to bedaquiline than Mycobacterium fortuitum, with MIC50 and MIC90 values of 0.13 and >16 mg/L, respectively, for both species. Bedaquiline also shows moderate in vitro activity against NTM species[2]. Bedaquiline has an excellent in vitro activity against Mycobacterium tuberculosis, including multidrug resistant M tuberculosis[3].
References

[1]. Jang JC, et al. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017 Apr 20.

[2]. Pang Y, et al. In Vitro Activity of Bedaquiline against Nontuberculous Mycobacteria in China. Antimicrob Agents Chemother. 2017 Apr 24;61(5).

[3]. Chahine EB, et al. Bedaquiline: a novel diarylquinoline for multidrug-resistant tuberculosis. Ann Pharmacother. 2014 Jan;48(1):107-15.

 Chemical & Physical Properties

Molecular Formula C36H35BrN2O6
Molecular Weight 671.577
Exact Mass 670.167847
PSA 120.19000
LogP 6.84230
Storage condition -20℃

 Synonyms

P04QX2C1A5
UNII-P04QX2C1A5
Sirturo
(1R,2S)-1-(6-Bromo-2-methoxy-3-quinolinyl)-4-(dimethylamino)-2-(1-naphthyl)-1-phenyl-2-butanol (2E)-2-butenedioate (1:1)
3-Quinolineethanol, 6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-, (αS,βR)-, (2E)-2-butenedioate (1:1) (salt)
bedaquiline fumarate
Bedaquiline (fumarate)
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Related Compounds: More...
cis-1-(6-Bromo-2-methoxyquinolin-3-yl)-4-(dimethylamino)-2-(naphthalen-1-yl)-1-phenylbutan-2-ol
654653-93-7
Bedaquiline
843663-66-1
Bedaquiline IMpurity
857086-92-1
Bedaquiline (1S,2S) Isomer Impurity 3
1972612-60-4
Bedaquiline Impurity 5
916801-19-9
Bedaquiline (Mixture of DiastereoMers)
654655-80-8
DIOCTYL FUMARATE
141-02-6
Pirepemat fumarate
2251806-70-7
Diisobutyl Fumarate
7283-69-4
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