XENALIPIN structure
|
Common Name | XENALIPIN | ||
---|---|---|---|---|
CAS Number | 84392-17-6 | Molecular Weight | 266.215 | |
Density | 1.3±0.1 g/cm3 | Boiling Point | 335.8±37.0 °C at 760 mmHg | |
Molecular Formula | C14H9F3O2 | Melting Point | 169-171 °C(lit.) | |
MSDS | Chinese USA | Flash Point | 156.9±26.5 °C |
Use of XENALIPIN4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent[1]. |
Name | 4-(Trifluoromethyl)biphenyl-2-carboxylic acid |
---|---|
Synonym | More Synonyms |
Description | 4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent[1]. |
---|---|
Related Catalog | |
In Vivo | 4'-Trifluoromethyl-2-biphenyl carboxylic acid (15-60 mg/kg, p.o., twice a day) shows hypolipidemic activity in diet-induced hypercholesterolemic African green monkeys[1]. Animal Model: Diet-induced hypercholesterolemic African green monkeys[5] Dosage: 15-60 mg/kg Administration: Oral administration (p.o.) Result: Reduced serum LDL-cholesterol concentrations. |
Density | 1.3±0.1 g/cm3 |
---|---|
Boiling Point | 335.8±37.0 °C at 760 mmHg |
Melting Point | 169-171 °C(lit.) |
Molecular Formula | C14H9F3O2 |
Molecular Weight | 266.215 |
Flash Point | 156.9±26.5 °C |
Exact Mass | 266.055450 |
PSA | 37.30000 |
LogP | 3.97 |
Vapour Pressure | 0.0±0.8 mmHg at 25°C |
Index of Refraction | 1.538 |
Storage condition | Room temperature. |
Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
---|---|
Hazard Codes | Xi |
Risk Phrases | R36/37/38 |
Safety Phrases | S26-S36/37/39 |
RIDADR | NONH for all modes of transport |
WGK Germany | 3 |
HS Code | 2916399090 |
Precursor 10 | |
---|---|
DownStream 2 | |
HS Code | 2916399090 |
---|---|
Summary | 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |
Evaluation of the hypolipidemic activity of xenalipin in experimental animals.
Atherosclerosis 64(1) , 27-35, (1987) Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in ser... |
|
The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin. Eaddy JF.
Org. Prep. Proced. Int. 27(3) , 367-72, (1995)
|
|
Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent. Hill JA and Eaddy JF.
J. Labelled Comp. Radiopharm. 31(12) , 1011-17, (1992)
|
XENALIPIN |
4'-(Trifluoromethyl)-2-biphenylcarboxylic acid |
4'-(trifluoromethyl)biphenyl-2-carboxylic acid |
2-[4-(trifluoromethyl)phenyl]benzoic acid |
MFCD00075353 |
[1,1'-Biphenyl]-2-carboxylic acid, 4'-(trifluoromethyl)- |
4'-(Trifluoromethyl)-1,1'-biphenyl-2-carboxylic Acid |
4-(Trifluoromethyl)-2'-biphenylcarboxylic acid |