XENALIPIN

Modify Date: 2024-01-09 13:21:50

XENALIPIN Structure
XENALIPIN structure
Common Name XENALIPIN
CAS Number 84392-17-6 Molecular Weight 266.215
Density 1.3±0.1 g/cm3 Boiling Point 335.8±37.0 °C at 760 mmHg
Molecular Formula C14H9F3O2 Melting Point 169-171 °C(lit.)
MSDS Chinese USA Flash Point 156.9±26.5 °C

 Use of XENALIPIN


4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent[1].

 Names

Name 4-(Trifluoromethyl)biphenyl-2-carboxylic acid
Synonym More Synonyms

 XENALIPIN Biological Activity

Description 4'-Trifluoromethyl-2-biphenyl carboxylic acid is an orally active hypolipidemic agent[1].
Related Catalog
In Vivo 4'-Trifluoromethyl-2-biphenyl carboxylic acid (15-60 mg/kg, p.o., twice a day) shows hypolipidemic activity in diet-induced hypercholesterolemic African green monkeys[1]. Animal Model: Diet-induced hypercholesterolemic African green monkeys[5] Dosage: 15-60 mg/kg Administration: Oral administration (p.o.) Result: Reduced serum LDL-cholesterol concentrations.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 335.8±37.0 °C at 760 mmHg
Melting Point 169-171 °C(lit.)
Molecular Formula C14H9F3O2
Molecular Weight 266.215
Flash Point 156.9±26.5 °C
Exact Mass 266.055450
PSA 37.30000
LogP 3.97
Vapour Pressure 0.0±0.8 mmHg at 25°C
Index of Refraction 1.538
Storage condition Room temperature.

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S26-S36/37/39
RIDADR NONH for all modes of transport
WGK Germany 3
HS Code 2916399090

 Synthetic Route

 Customs

HS Code 2916399090
Summary 2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

 Articles3

More Articles
Evaluation of the hypolipidemic activity of xenalipin in experimental animals.

Atherosclerosis 64(1) , 27-35, (1987)

Xenalipin (4'-trifluoromethyl-2-biphenylcarboxylic acid) is a chemically novel compound which has been found to be an effective hypolipidemic agent in two animal species. Significant reductions in ser...

The Nickel (I) Catalyzed Coupling of a Diarylzinc with an Aryl Chloride in the Synthesis of Xenalipin. Eaddy JF.

Org. Prep. Proced. Int. 27(3) , 367-72, (1995)

Synthesis of carbon-14 labelled xenalipin-a potential hypolipidemic agent. Hill JA and Eaddy JF.

J. Labelled Comp. Radiopharm. 31(12) , 1011-17, (1992)

 Synonyms

XENALIPIN
4'-(Trifluoromethyl)-2-biphenylcarboxylic acid
4'-(trifluoromethyl)biphenyl-2-carboxylic acid
2-[4-(trifluoromethyl)phenyl]benzoic acid
MFCD00075353
[1,1'-Biphenyl]-2-carboxylic acid, 4'-(trifluoromethyl)-
4'-(Trifluoromethyl)-1,1'-biphenyl-2-carboxylic Acid
4-(Trifluoromethyl)-2'-biphenylcarboxylic acid
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