STX-0119
Modify Date: 2024-01-10 13:03:32
STX-0119 structure
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Common Name | STX-0119 | ||
|---|---|---|---|---|
| CAS Number | 851095-32-4 | Molecular Weight | 382.37200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H14N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of STX-0119STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1]. |
| Name | 4-Quinolinecarboxamide, N-[5-(2-furanyl)-1,3,4-oxadiazol-2-yl]-2-phenyl |
|---|---|
| Synonym | More Synonyms |
| Description | STX-0119 is a selective, orally active STAT3 dimerization inhibitor. STX-0119 inhibits STAT3 transcription with an IC50 of 74 μM[1]. |
|---|---|
| Related Catalog | |
| Target |
STAT3:74 μM (IC50, STAT3 transcription) |
| In Vitro | STX-0119 (10-50 μM; 24 h) inhibits STAT3 dimerization through a direct interaction with the STAT3 protein and not via the modulation of upstream regulators such as JAK in HEK293 and MDA-MB-468 cells[1]. STX-0119 (10-50 μM; 24 h) reduces the expression of STAT3 target proteins[1]. Western Blot Analysis[1] Cell Line: MDA-MB-468 cells Concentration: 10, 20 and 50 μM Incubation Time: 24 h Result: Reduced the expression of STAT3 target proteins, namely, c-myc, cyclin D1, and survivin, in a concentration-dependent manner. Did not suppress the expression of those STAT3-regulated oncoproteins. |
| In Vivo | STX-0119 (160 mg/kg; oral gavage; daily for 4 days) inhibits SCC-3 tumor growth in mice[1]. The plasma concentration of STX-0119 (160 mg/kg; oral gavage) is maintained at >100 μg/mL (>260 μM), even at 8 h after administration[1]. Animal Model: Male BALB/cA-ν/ν nude mice, SCC-3 lymphoma xenograft model[1] Dosage: 160 mg/kg Administration: Oral gavage, daily for 4 days Result: Suppressed the growth of SCC-3 cells significantly on the fourth day. |
| Molecular Formula | C22H14N4O3 |
|---|---|
| Molecular Weight | 382.37200 |
| Exact Mass | 382.10700 |
| PSA | 94.05000 |
| LogP | 4.87010 |
| Storage condition | 2-8°C |
| Stx 0119 |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: STX-0119
- Price: Negotiable
- Purity: 99.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- DC Chemicals Limited
- China
- Product Name: STX-0119
- Price: ￥Inquiry/100mg ￥Inquiry/250mg ￥Inquiry/1g
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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