MB-07811
Modify Date: 2024-01-08 16:34:15
MB-07811 structure
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Common Name | MB-07811 | ||
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| CAS Number | 852948-13-1 | Molecular Weight | 514.98 | |
| Density | 1.27±0.1 g/cm3(Predicted) | Boiling Point | 660.6±55.0 °C(Predicted) | |
| Molecular Formula | C28H32ClO5P | Melting Point | 77-82 °C | |
| MSDS | N/A | Flash Point | N/A | |
Use of MB-07811MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2]. |
| Name | 4-[[4-[[(2R,4S)-4-(3-chlorophenyl)-2-oxo-1,3,2λ5-dioxaphosphinan-2-yl]methoxy]-2,6-dimethylphenyl]methyl]-2-propan-2-ylphenol |
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| Description | MB-07811 (VK-2809) is an orally active HepDirect prodrug of MB07344, a liver-targeted thyroid hormone receptor-β agonist[1]. MB-07811 has cholesterol and triglycerides lowering activity[2]. |
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| Related Catalog | |
| Target |
Thyroid hormone receptor-β[2] |
| In Vitro | MB-07811 is potential for liver targeting with a low affinity for thyroid hormone receptors (TRβ Ki = 14.6 ± 0.5 μM; TRα Ki = 12.5 ± 0.6 μM)[2]. |
| In Vivo | MB-07811 (0.3-30 mg/kg; orally once daily for 14 days) reduces cholesterol and triglycerides in diet-induced obese mice[2]. Animal Model: 4-week-old male C57BL/6 mice (diet-induced obese (DIO) mice)[2] Dosage: 0.3 mg/kg, 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg Administration: Orally once daily; 14 days Result: Reduced total plasma cholesterol, and reduced plasma triglycerides (40%) at the highest doses. |
| References |
| Density | 1.27±0.1 g/cm3(Predicted) |
|---|---|
| Boiling Point | 660.6±55.0 °C(Predicted) |
| Melting Point | 77-82 °C |
| Molecular Formula | C28H32ClO5P |
| Molecular Weight | 514.98 |
| Exact Mass | 514.16800 |
| PSA | 74.80000 |
| LogP | 8.08420 |
| Storage condition | 2-8°C |