Safflor yellow A

Modify Date: 2024-01-06 16:58:44

Safflor yellow A Structure
Safflor yellow A structure
 Common Name Safflor yellow A
CAS Number 85532-77-0 Molecular Weight 610.51700
Density 1.81g/cm3 Boiling Point 942.3ºC at 760 mmHg
Molecular Formula C27H30O15 Melting Point N/A
MSDS N/A Flash Point 313ºC

 Use of Safflor yellow A


Safflor yellow A, a flavonoid extracted from Carthamus tinctorius L, is a water-soluble monomer of safflor yellow. Safflor yellow A protects rat cardiomyocytes against anoxia/reoxygenation (A/R) injury via inhibiting cellular oxidative stress and apoptosis[1].

 Names

Name safflor yellow (A)

 Safflor yellow A Biological Activity

Description Safflor yellow A, a flavonoid extracted from Carthamus tinctorius L, is a water-soluble monomer of safflor yellow. Safflor yellow A protects rat cardiomyocytes against anoxia/reoxygenation (A/R) injury via inhibiting cellular oxidative stress and apoptosis[1].
Related Catalog
In Vivo Pretreatment with Safflor yellow A (40, 60 and 80 nM) concentration-dependently blockes the A/R-induced changes in the cardiomyocytes in 1- to 3-d-old Sprague-Dawley rats [1].
References

[1]. Duan JL, et al. Safflor yellow A protects neonatal rat cardiomyocytes against anoxia/reoxygenation injury in vitro. Acta Pharmacol Sin. 2013 Apr;34(4):487-95.

 Chemical & Physical Properties

Density 1.81g/cm3
Boiling Point 942.3ºC at 760 mmHg
Molecular Formula C27H30O15
Molecular Weight 610.51700
Flash Point 313ºC
Exact Mass 610.15300
PSA 273.36000
Index of Refraction 1.764

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UQ0333750
CHEMICAL NAME :
9H-Pyrano(3,2-b)benzofuran-9-one, 2,3,4,4a,6,9b-hexahydro-6-beta-D-glucopyranosyl-2- (hydroxymethyl)-8-(3-(4-hydroxyphenyl)-1-oxo-2-propen yl)-3,4,6,7-tetrahydr oxy-
CAS REGISTRY NUMBER :
85532-77-0
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C27-H30-O15
MOLECULAR WEIGHT :
594.57

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5530 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5490 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - respiratory stimulation
REFERENCE :
CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 15,348,1984
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