DNP-PEG4-acid

Modify Date: 2024-01-08 18:16:43

DNP-PEG4-acid Structure
DNP-PEG4-acid structure
Common Name DNP-PEG4-acid
CAS Number 858126-76-8 Molecular Weight 431.39500
Density N/A Boiling Point N/A
Molecular Formula C17H25N3O10 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of DNP-PEG4-acid


DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Propanoic acid, 3-[2-[2-[2-[2-[(2,4-dinitrophenyl)amino]ethoxy]ethoxy]ethoxy]ethoxy]
Synonym More Synonyms

 DNP-PEG4-acid Biological Activity

Description DNP-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C17H25N3O10
Molecular Weight 431.39500
Exact Mass 431.15400
PSA 177.89000
LogP 2.57540

 Synonyms

DNP-PEG4-ACID
3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-[(2,4-dinitrophenyl)amino]-
DNP-NH-PEG(4)-COOH 1-(2,4-DINITROPHENYLAMINO)-3,6,9,12-TETRAOXAPENTADECANOIC ACID
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