| In Vivo |
Human SP-B gene but not mouse SP-B is expressed in the lung of hTG SP-B-C and SP-B-T mice. For infected SP-B-C mice, the levels of bioluminescence increase rapidly from 0 to 24h after infection, remains high between 24 and 32 h, and then decreases; the bioluminescence levels are significantly lower (p<0.01) in the CMC2.24 treated group from 24 to 48 h after infection. In infected SP-B-T mice, the peak time of bioluminescence is at 12 h after infection, then the level decreases slowly. Lung tissues from of infected SP-B-C mice showed more apoptotic cells compared to infected SP-B-T mice. CMC2.24 treated SP-B-C and SP-B-T mice have decreased MMP-2, -9, and -12 activities compared to their respective untreated groups[1].
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