1-(3,4-DICHLOROBENZYL)PIPERAZINE

Modify Date: 2024-01-02 20:51:14

1-(3,4-DICHLOROBENZYL)PIPERAZINE structure	Common Name	1-(3,4-DICHLOROBENZYL)PIPERAZINE
	CAS Number	86215-36-3	Molecular Weight	264.58
	Density	N/A	Boiling Point	324.4ºC at 760 mmHg
	Molecular Formula	C₁₁H₁₂Cl₃N	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	150ºC
	Symbol	GHS06	Signal Word	Danger

Use of 1-(3,4-DICHLOROBENZYL)PIPERAZINE

DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].

Name	1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane,hydrochloride
Synonym	More Synonyms

Description	DOV-216,303 is an antidepressant compound. DOV-216,303 inhibits the reuptake of norepinephrine (NE), serotonin (5‐HT), and dopamine (DA), with IC50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. DOV-216,303 increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> Serotonin Transporter
Target	14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT[2]
References	[1]. Skolnick P, et al. Preclinical and clinical pharmacology of DOV 216,303, a "triple" reuptake inhibitor. CNS Drug Rev. 2006 Summer;12(2):123-34. [2]. Shao L, et al. Discovery of N-methyl-1-(1-phenylcyclohexyl)methanamine, a novel triple serotonin, norepinephrine, and dopamine reuptake inhibitor. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1438-41. [3]. Prins J, et al. The putative antidepressant DOV 216,303, a triple reuptake inhibitor, increases monoamine release in the prefrontal cortex of olfactory bulbectomized rats. Eur J Pharmacol. 2010 May 10;633(1-3):55-61.

Boiling Point	324.4ºC at 760 mmHg
Molecular Formula	C₁₁H₁₂Cl₃N
Molecular Weight	264.58
Flash Point	150ºC
Exact Mass	263.00400
PSA	12.03000
LogP	3.98510

1-(3,4-DICHLOROBENZYL)PIPERAZINE MSDS(Chinese)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H319
Precautionary Statements	P301 + P310-P305 + P351 + P338
RIDADR	UN 2811 6.1 / PGIII
HS Code	2933990090

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Literature: Hagen, Eric J.; Halloran, Kevin Patent: US2007/43100 A1, 2007 ; Location in patent: Page/Page column 10-11 ;

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